C-reactive protein, APOE genotype and longitudinal cognitive change in an older population

on behalf of the Medical Research Council Cognitive Function and Ageing Study; Thomas A S Lima; Amanda L Adler; Thais Minett; Fiona E Matthews; Carol Brayne; Riccardo E Marioni

doi:10.1093/ageing/aft193

C-reactive protein, APOE genotype and longitudinal cognitive change in an older population

on behalf of the Medical Research Council Cognitive Function and Ageing Study, Thomas A S Lima, Amanda L Adler, Thais Minett, Fiona E Matthews, Carol Brayne, Riccardo E Marioni

Research output: Contribution to journal › Article › peer-review

Abstract

circulating measures of inflammatory markers, such as C-reactive protein (CRP) have been associated with an increased risk of future cognitive decline. However, the nature of the relationship among the very old (>75 years) is unclear. Cross-sectional evidence suggests that elevated CRP may even be protective in this age group. This study examines these associations longitudinally.

Original language	English
Journal	Age and Ageing
Volume	43
Issue number	2
Early online date	3 Dec 2013
DOIs	https://doi.org/10.1093/ageing/aft193
Publication status	Published - Mar 2014

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10.1093/ageing/aft193

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title = "C-reactive protein, APOE genotype and longitudinal cognitive change in an older population",

abstract = "circulating measures of inflammatory markers, such as C-reactive protein (CRP) have been associated with an increased risk of future cognitive decline. However, the nature of the relationship among the very old (>75 years) is unclear. Cross-sectional evidence suggests that elevated CRP may even be protective in this age group. This study examines these associations longitudinally.",

author = "{on behalf of the Medical Research Council Cognitive Function and Ageing Study} and Lima, {Thomas A S} and Adler, {Amanda L} and Thais Minett and Matthews, {Fiona E} and Carol Brayne and Marioni, {Riccardo E}",

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C-reactive protein, APOE genotype and longitudinal cognitive change in an older population. / on behalf of the Medical Research Council Cognitive Function and Ageing Study; Lima, Thomas A S; Adler, Amanda L; Minett, Thais; Matthews, Fiona E; Brayne, Carol; Marioni, Riccardo E.

In: Age and Ageing, Vol. 43, No. 2, 03.2014.

Research output: Contribution to journal › Article › peer-review

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AU - on behalf of the Medical Research Council Cognitive Function and Ageing Study

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AU - Adler, Amanda L

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AU - Marioni, Riccardo E

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AB - circulating measures of inflammatory markers, such as C-reactive protein (CRP) have been associated with an increased risk of future cognitive decline. However, the nature of the relationship among the very old (>75 years) is unclear. Cross-sectional evidence suggests that elevated CRP may even be protective in this age group. This study examines these associations longitudinally.

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DO - 10.1093/ageing/aft193

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VL - 43

JO - Age and Ageing

JF - Age and Ageing

SN - 0002-0729

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C-reactive protein, APOE genotype and longitudinal cognitive change in an older population

Abstract

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