C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis

Cristina Perez-Ternero, Aisah A Aubdool, Raj Makwana, Gareth J Sanger, Roland H Stimson, Li F Chan, Amie J. Moyes, Adrian J Hobbs*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

SignificanceThe global mortality, morbidity, and healthcare costs associated with cardiometabolic disease, including obesity, diabetes, hypertension, and dyslipidemia, are substantial and represent an expanding unmet medical need. Herein, we have identified a physiological role for C-type natriuretic peptide (CNP) in regulating key processes, including thermogenesis and adipogenesis, which combine to coordinate metabolic function and prevent the development of cardiometabolic disorders. This protective mechanism, which is in part mediated via an autocrine action of CNP on adipocytes, is underpinned by activation of cognate natriuretic peptide receptors (NPR)-B and NPR-C. This mechanism advances the fundamental understanding of energy homeostasis and glucose handling and offers the promise of improving the treatment of cardiometabolic disease.
Original languageEnglish
JournalProceedings of the National Academy of Sciences
DOIs
Publication statusPublished - 25 Mar 2022

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