TY - JOUR
T1 - C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis
AU - Perez-Ternero, Cristina
AU - Aubdool, Aisah A
AU - Makwana, Raj
AU - Sanger, Gareth J
AU - Stimson, Roland H
AU - Chan, Li F
AU - Moyes, Amie J.
AU - Hobbs, Adrian J
N1 - Funding Information:
ACKNOWLEDGMENTS. This work was funded by British Heart Foundation Programme Grant RG/16/7/32357 (to A.J.H.). R.H.S. is supported by the Chief Scientist Office (SCAF/17/02). L.F.C. is supported by grants from the Medical Research Council (MRC G0802796) and the Wellcome Trust (217543/Z/19/Z).
Publisher Copyright:
Copyright © 2022 the Author(s).
PY - 2022/3/25
Y1 - 2022/3/25
N2 - SignificanceThe global mortality, morbidity, and healthcare costs associated with cardiometabolic disease, including obesity, diabetes, hypertension, and dyslipidemia, are substantial and represent an expanding unmet medical need. Herein, we have identified a physiological role for C-type natriuretic peptide (CNP) in regulating key processes, including thermogenesis and adipogenesis, which combine to coordinate metabolic function and prevent the development of cardiometabolic disorders. This protective mechanism, which is in part mediated via an autocrine action of CNP on adipocytes, is underpinned by activation of cognate natriuretic peptide receptors (NPR)-B and NPR-C. This mechanism advances the fundamental understanding of energy homeostasis and glucose handling and offers the promise of improving the treatment of cardiometabolic disease.
AB - SignificanceThe global mortality, morbidity, and healthcare costs associated with cardiometabolic disease, including obesity, diabetes, hypertension, and dyslipidemia, are substantial and represent an expanding unmet medical need. Herein, we have identified a physiological role for C-type natriuretic peptide (CNP) in regulating key processes, including thermogenesis and adipogenesis, which combine to coordinate metabolic function and prevent the development of cardiometabolic disorders. This protective mechanism, which is in part mediated via an autocrine action of CNP on adipocytes, is underpinned by activation of cognate natriuretic peptide receptors (NPR)-B and NPR-C. This mechanism advances the fundamental understanding of energy homeostasis and glucose handling and offers the promise of improving the treatment of cardiometabolic disease.
U2 - 10.1073/pnas.2116470119
DO - 10.1073/pnas.2116470119
M3 - Article
SN - 0027-8424
JO - Proceedings of the National Academy of Sciences (PNAS)
JF - Proceedings of the National Academy of Sciences (PNAS)
ER -