Abstract / Description of output
The gonadotropin-releasing hormone (GnRH) neurons represent the key output cells of the neuronal network controlling fertility. Intracellular calcium ion concentration ([Ca(2+)](i)) is likely to be a key signaling tool used by GnRH neurons to regulate and co-ordinate multiple cell processes. This review examines the dynamics and control of [Ca(2+)](i) in GT1 cells, embryonic GnRH neurons in the nasal placode culture, and adult GnRH neurons in the acute brain slice preparation. GnRH neurons at all stages of development display spontaneous [Ca(2+)](i) transients driven, primarily, by their burst firing. However, the intracellular mechanisms generating [Ca(2+)](i) transients, and the control of [Ca(2+)](i) by neurotransmitters, varies markedly across the different developmental stages. The functional roles of [Ca(2+)](i) transients are beginning to be unraveled with one key action being that of regulating the dynamics of GnRH neuron burst firing. (C) 2010 Elsevier Inc. All rights reserved.
Original language | English |
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Pages (from-to) | 259-269 |
Number of pages | 11 |
Journal | Frontiers in neuroendocrinology |
Volume | 31 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jul 2010 |
Keywords / Materials (for Non-textual outputs)
- GnRH
- LHRH
- Calcium
- GABA
- Glutamate
- Electrophysiology
- Monkey
- Mouse
- GT1
- Embryo
- EMBRYONIC OLFACTORY PLACODE
- HYPOTHALAMIC GT1-7 NEURONS
- RAT SUPRAOPTIC NUCLEUS
- ACTIVATED POTASSIUM CHANNELS
- NUCLEOTIDE-GATED CHANNELS
- GAMMA-AMINOBUTYRIC-ACID
- PRIMARY-CELL CULTURE
- SMOOTH-MUSCLE-CELLS
- GNRH NEURONS
- INTRACELLULAR CA2+