Calcium dynamics in gonadotropin-releasing hormone neurons

Christine L. Jasoni, Nicola Romano, Stephanie Constantin, Kiho Lee, Allan E. Herbison*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The gonadotropin-releasing hormone (GnRH) neurons represent the key output cells of the neuronal network controlling fertility. Intracellular calcium ion concentration ([Ca(2+)](i)) is likely to be a key signaling tool used by GnRH neurons to regulate and co-ordinate multiple cell processes. This review examines the dynamics and control of [Ca(2+)](i) in GT1 cells, embryonic GnRH neurons in the nasal placode culture, and adult GnRH neurons in the acute brain slice preparation. GnRH neurons at all stages of development display spontaneous [Ca(2+)](i) transients driven, primarily, by their burst firing. However, the intracellular mechanisms generating [Ca(2+)](i) transients, and the control of [Ca(2+)](i) by neurotransmitters, varies markedly across the different developmental stages. The functional roles of [Ca(2+)](i) transients are beginning to be unraveled with one key action being that of regulating the dynamics of GnRH neuron burst firing. (C) 2010 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)259-269
Number of pages11
JournalFrontiers in neuroendocrinology
Volume31
Issue number3
DOIs
Publication statusPublished - Jul 2010

Keywords

  • GnRH
  • LHRH
  • Calcium
  • GABA
  • Glutamate
  • Electrophysiology
  • Monkey
  • Mouse
  • GT1
  • Embryo
  • EMBRYONIC OLFACTORY PLACODE
  • HYPOTHALAMIC GT1-7 NEURONS
  • RAT SUPRAOPTIC NUCLEUS
  • ACTIVATED POTASSIUM CHANNELS
  • NUCLEOTIDE-GATED CHANNELS
  • GAMMA-AMINOBUTYRIC-ACID
  • PRIMARY-CELL CULTURE
  • SMOOTH-MUSCLE-CELLS
  • GNRH NEURONS
  • INTRACELLULAR CA2+

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