Calcium imaging in the living brain: prospects for molecular medicine

Nathalie Rochefort, Hongbo Jia, Arthur Konnerth*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Calcium imaging has revolutionized the approaches for functional analyses in the living brain of animal experimental models: Changes in intracellular calcium concentration are strictly linked to the electrical activity in neurons and produce signals that are effectively detected by optical methods. Distinctive features of fluorescence-based calcium imaging are its high temporal resolution in the millisecond range and its high spatial resolution in the micrometer range. Recent progress includes the development of fluorometric calcium sensors, new approaches for targeted labeling with these sensors and the implementation of powerful imaging techniques, especially two-photon microscopy. An important and rapidly evolving field of current research is the use of calcium imaging for the analysis of in vivo mouse models for various brain diseases, such as Alzheimer's disease, stroke and epilepsy.

Original languageEnglish
Pages (from-to)389-399
Number of pages11
JournalTrends in Molecular Medicine
Volume14
Issue number9
DOIs
Publication statusPublished - Sept 2008

Keywords / Materials (for Non-textual outputs)

  • AMYOTROPHIC-LATERAL-SCLEROSIS
  • AMYLOID-BETA PLAQUES
  • RAT BARREL CORTEX
  • IN-VIVO
  • OLFACTORY-BULB
  • ALZHEIMERS-DISEASE
  • TRANSGENIC MICE
  • VISUAL-CORTEX
  • PYRAMIDAL NEURONS
  • NERVOUS-SYSTEM

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