Calcium release dynamics in clusters of IP3 channels

Svitlana Braichenko, Srinandan Dasmahapatra, Atul Bhaskar

Research output: Contribution to conferencePosterpeer-review


Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves and oscillations that occur on multiple spatial and temporal scales. We introduce a minimal yet descriptive reaction- diffusion model of IP3 receptors for a saturating concentration of IP3 using a principled reduction of a detailed Markov chain description of individual channels. A dynamical systems analysis reveals the possibility of excitable, bistable and oscillatory dynamics of this model that correspond to three types of observed patterns of calcium releases -- puffs, waves and spikes respectively. We explain the emergence of these patterns via a bifurcation analysis of a coupled two-cluster model, compute the phase diagram and quantify the speed of the waves and period of oscillations in terms of system parameters.
Original languageEnglish
Number of pages1
Publication statusPublished - 25 Sep 2017
EventEMBO workshop, LabEx INFORM: Dynamics of Living Systems - Cargèse, France
Duration: 25 Sep 201729 Sep 2019


WorkshopEMBO workshop, LabEx INFORM: Dynamics of Living Systems
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