Abstract / Description of output
Clusters of IP3 receptor channels in the membranes of the endoplasmic reticulum (ER) of many non-excitable cells release calcium ions in a cooperative manner giving rise to dynamical patterns such as Ca2+ puffs, waves and oscillations that occur on multiple spatial and temporal scales. We introduce a minimal yet descriptive reaction- diffusion model of IP3 receptors for a saturating concentration of IP3 using a principled reduction of a detailed Markov chain description of individual channels. A dynamical systems analysis reveals the possibility of excitable, bistable and oscillatory dynamics of this model that correspond to three types of observed patterns of calcium releases -- puffs, waves and spikes respectively. We explain the emergence of these patterns via a bifurcation analysis of a coupled two-cluster model, compute the phase diagram and quantify the speed of the waves and period of oscillations in terms of system parameters.
Original language | English |
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Pages | 79 |
Number of pages | 1 |
Publication status | Published - 25 Sept 2017 |
Event | EMBO workshop, LabEx INFORM: Dynamics of Living Systems - Cargèse, France Duration: 25 Sept 2017 → 29 Sept 2019 http://meetings.embo.org/events/17-dynamics |
Workshop
Workshop | EMBO workshop, LabEx INFORM: Dynamics of Living Systems |
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Country/Territory | France |
City | Cargèse |
Period | 25/09/17 → 29/09/19 |
Internet address |