Calculated free testosterone in men: comparison of four equations and with free androgen index

Clement K M Ho, Mary Stoddart, Melanie Walton, Richard A Anderson, Geoffrey J Beckett

Research output: Contribution to journalArticlepeer-review

Abstract

Serum testosterone remains the most important investigation in the diagnosis of androgen deficiency in men. Most of the circulating testosterone is bound to albumin and sex hormone-binding globulin (SHBG), whereas free testosterone accounts for approximately 2% of total testosterone. Because direct measurement of free testosterone is impractical in routine practice, several equations are used to provide clinically useful estimates of free testosterone concentration. This study aimed to (1) obtain locally derived reference limits for total testosterone and calculated free testosterone (CFT) concentrations, and (2) critically evaluate the equations commonly used to estimate free testosterone.
Original languageEnglish
Pages (from-to)389-97
Number of pages9
JournalAnnals of clinical biochemistry
Volume43
Issue numberPt 5
Publication statusPublished - 2006

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