Calculation of sample size for stroke trials assessing functional outcome: comparison of binary and ordinal approaches

Optimising Analysis of Stroke Trials Collaboration, Martin Dennis, Stephanie Lewis, Joanna Wardlaw

Research output: Contribution to journalArticlepeer-review

Abstract

Many acute stroke trials have given neutral results. Sub-optimal statistical analyses may be failing to detect efficacy. Methods which take account of the ordinal nature of functional outcome data are more efficient. We compare sample size calculations for dichotomous and ordinal outcomes for use in stroke trials.
Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalInternational Journal of Stroke
Volume3
Issue number2
DOIs
Publication statusPublished - 1 May 2008

Keywords

  • Clinical Trials as Topic
  • Humans
  • Reproducibility of Results
  • Sample Size
  • Stroke
  • Treatment Outcome

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