Calpain :a role in cell transformation and migration

Research output: Contribution to journalReview articlepeer-review

Abstract

Calpains represent a well conserved family of calcium-dependent proteolytic enzymes. Recent progress in determining the three-dimensional crystal structure of calpains and generation of calpain knock out animals have significantly advanced our understanding of both the activation mechanism and physiological role of this protease family. Studies applying molecular intervention strategies and genetic ablation of calpain now provide indisputable evidence that calpain activity contributes to remodelling of the actin cytoskeleton, cell migration and oncogenic transformation. Src and epidermal growth factor receptor (EGFR) stimulated cell motility is dependent upon calpain activation. In addition, calpain promotes accelerated cell-cycle progression and anchorage-independent growth of Src transformed cells. In vivo studies demonstrate a link between calpain expression levels and activity with tumour development and invasion. Thus, recent investigations suggest that the role of calpain in promoting cell transformation and cell migration may have important in vivo consequences in the context of cancer pathobiology.

Original languageEnglish
Pages (from-to)1539-43
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume34
Issue number12
DOIs
Publication statusPublished - Dec 2002

Keywords

  • Animals
  • Calpain/chemistry
  • Cell Movement/physiology
  • Cell Transformation, Neoplastic
  • Humans
  • Neoplasms/enzymology
  • Protein Conformation

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