Cambridge Hybrid Closed-Loop System in Very Young Children With Type 1 Diabetes Reduces Caregivers’ Fear of Hypoglycemia and Improves Their Well-Being

KidsAP Consortium, Carine De Beaufort, Ulrike Schierloh, Ajay Thankamony, Julia Ware, Malgorzata E. Wilinska, Elke Fröhlich-reiterer, Thomas M. Kapellen, Birgit Rami-merhar, Sabine E. Hofer, Fiona M Campbell, James Yong, Laura E. Bocchino, Judy Sibayan, Julia Lawton, Stephane Roze, Maria Fritsch, Alena Thiele, Janet M. Allen, Charlotte BoughtonJulia K. Mader, Craig Kollman, Roman Hovorka, Ineke M. Pit-ten Cate

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE
To evaluate the impact of CamAPS FX hybrid closed-loop (HCL) automated insulin delivery in very young children with type 1 diabetes (T1D) on caregivers’ well-being, fear of hypoglycemia, and sleepiness.

RESEARCH DESIGN AND METHODS
We conducted a multinational, open-label, randomized crossover study. Children (age 1–7 years) with T1D received treatment for two 4-month periods in random order, comparing HCL with sensor augmented pump (control). At baseline and after each treatment period, caregivers were invited to complete World Health Organization–Five Well-Being Index, Hypoglycemia Fear Survey, and Epworth Sleepiness Scale questionnaires.

RESULTS
Caregivers of 74 children (mean ± SD age 5 ± 2 years and baseline HbA1c 7.3 ± 0.7%; 42% female) participated. Results revealed significantly lower scores for hypoglycemia fear (P < 0.001) and higher scores for well-being (P < 0.001) after HCL treatment. A trend toward a reduction in sleepiness score was observed (P = 0.09).

CONCLUSIONS
Our results suggest better well-being and less hypoglycemia fear in caregivers of very young children with T1D on CamAPS FX HCL.
Original languageEnglish
Pages (from-to)3050-3053
Number of pages4
JournalDiabetes Care
Volume45
Issue number2
Early online date16 Sept 2022
DOIs
Publication statusE-pub ahead of print - 16 Sept 2022

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