Campylobacter colonization of the chicken induces a proinflammatory response in mucosal tissues

C.K. Smith, M. Abuoun, S.A. Cawthraw, T.J. Humphrey, L. Rothwell, P. Kaiser, P.A. Barrow, M.A. Jones

Research output: Contribution to journalArticlepeer-review

Abstract

Campylobacter jejuni is a major cause of human inflammatory enteritis, but colonizes the gastrointestinal tract of poultry to a high level in a commensal manner. In vitro, C. jejuni induces the production of cytokines from both human and avian-model epithelial cell and macrophage infections. This suggests that, in vivo, Campylobacter could induce proinflammatory signals in both hosts. We investigated whether a proinflammatory cytokine response can be measured in both day-of-hatch and 2-week-old Light Sussex chickens during infection with C. jejuni. A significant induction of proinflammatory chemokine transcript was observed in birds of both ages, compared with levels in mock-infected controls. This correlated with an influx of heterophils but was not associated with any pathology. These results suggest that in poultry there may be a controlled inflammatory process during colonization.
Original languageUndefined/Unknown
Pages (from-to)114-121
Number of pages8
JournalFEMS Immunology and Medical Microbiology
Volume54
Issue number1
DOIs
Publication statusPublished - 2008

Keywords

  • Animals
  • Campylobacter Infections
  • Campylobacter jejuni
  • Cecum/immunology
  • Cecum/microbiology
  • Chickens
  • Colony Count, Microbial
  • Cytokines
  • Ileum
  • Intestinal Mucosa
  • Poultry Diseases
  • Specific Pathogen-Free Organisms

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