Abstract
Campylobacter jejuni is a major cause of human inflammatory enteritis, but colonizes the gastrointestinal tract of poultry to a high level in a commensal manner. In vitro, C. jejuni induces the production of cytokines from both human and avian-model epithelial cell and macrophage infections. This suggests that, in vivo, Campylobacter could induce proinflammatory signals in both hosts. We investigated whether a proinflammatory cytokine response can be measured in both day-of-hatch and 2-week-old Light Sussex chickens during infection with C. jejuni. A significant induction of proinflammatory chemokine transcript was observed in birds of both ages, compared with levels in mock-infected controls. This correlated with an influx of heterophils but was not associated with any pathology. These results suggest that in poultry there may be a controlled inflammatory process during colonization.
Original language | Undefined/Unknown |
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Pages (from-to) | 114-121 |
Number of pages | 8 |
Journal | FEMS Immunology and Medical Microbiology |
Volume | 54 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2008 |
Keywords
- Animals
- Campylobacter Infections
- Campylobacter jejuni
- Cecum/immunology
- Cecum/microbiology
- Chickens
- Colony Count, Microbial
- Cytokines
- Ileum
- Intestinal Mucosa
- Poultry Diseases
- Specific Pathogen-Free Organisms