Can viral envelope glycolipids produce auto-immunity, with reference to the CNS and multiple sclerosis?

H E Webb, J K Fazakerley

Research output: Contribution to journalArticlepeer-review

Abstract

Many viruses, with lipid envelopes derived from the host cell membranes, have been implicated in the aetiology of multiple sclerosis (MS), and epidemiological studies support an infectious agent. Alternatively the disease is thought by other workers to be auto-immune in nature, and recently much attention has been focused on immunological sensitivity to glycolipids in MS patients. In this paper it is proposed that CNS demyelination could arise in susceptible individuals (HLA type) from an immune response to glycolipids, triggered by the carrier effect of one or more enveloped neurotropic viruses.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalNeuropathology and Applied Neurobiology
Volume10
Issue number1
DOIs
Publication statusPublished - 1984

Keywords

  • Animals
  • Autoimmune Diseases
  • Central Nervous System
  • Central Nervous System Diseases
  • Chick Embryo
  • Cross Reactions
  • Demyelinating Diseases
  • Glycolipids
  • Membrane Lipids
  • Mice
  • Multiple Sclerosis
  • Nervous System Diseases
  • Pan troglodytes
  • Semliki forest virus
  • Togaviridae Infections

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