TY - JOUR
T1 - Can we manipulate the ovary’s own metabolism to protect it from chemotherapy-induced damage?
AU - Liugaila, Adomas
AU - Stefansdottir, Agnes
AU - Spears, Norah
N1 - ©The Author(s) 2024
PY - 2024/9/3
Y1 - 2024/9/3
N2 - Some chemotherapy treatments induce female infertility through accelerated ovarian ageing, including due to nicotinamide adenine dinucleotide (NAD) depletion. Using various mouse models, Ho et al (2024) demonstrate that exposure to two such chemotherapy drugs, cisplatin or doxorubicin, deplete ovarian NAD, with levels restored by administrating the exogenous NAD precursor nicotinamide mononucleotide, ameliorating the drugs’ damaging effects on fertility.
AB - Some chemotherapy treatments induce female infertility through accelerated ovarian ageing, including due to nicotinamide adenine dinucleotide (NAD) depletion. Using various mouse models, Ho et al (2024) demonstrate that exposure to two such chemotherapy drugs, cisplatin or doxorubicin, deplete ovarian NAD, with levels restored by administrating the exogenous NAD precursor nicotinamide mononucleotide, ameliorating the drugs’ damaging effects on fertility.
U2 - 10.1038/s44321-024-00124-z
DO - 10.1038/s44321-024-00124-z
M3 - Book/Film/Article review
C2 - 39227717
SN - 1757-4676
VL - 16
SP - 2274
EP - 2275
JO - EMBO Molecular Medicine
JF - EMBO Molecular Medicine
IS - 10
ER -