TY - JOUR
T1 - Cancer Associated Fibroblasts - An Impediment to Effective Anti-Cancer T Cell Immunity
AU - Koppensteiner, Lilian
AU - Mathieson, Layla
AU - O’Connor, Richard A.
AU - Akram, Ahsan R.
N1 - Publisher Copyright:
Copyright © 2022 Koppensteiner, Mathieson, O’Connor and Akram.
PY - 2022/4/11
Y1 - 2022/4/11
N2 - The presence of functionally efficient cytotoxic T lymphocytes (CTL) in the Tumour nest is crucial in mediating a successful immune response to cancer. The detection and elimination of cancer cells by CTL can be impaired by cancer-mediated immune evasion. In recent years, it has become increasingly clear that not only neoplastic cells themselves, but also cells of the tumour microenvironment (TME) exert immunosuppressive functions and thereby play an integral part in the immune escape of cancer. The most abundant stromal cells of the TME, cancer associated fibroblasts (CAFs), promote tumour progression via multiple pathways and play a role in dampening the immune response to cancer. Recent research indicates that T cells react to CAF signalling and establish bidirectional crosstalk that plays a significant role in the tumour immune response. This review discusses the various mechanisms by which the CAF/T cell crosstalk may impede anti-cancer immunity.
AB - The presence of functionally efficient cytotoxic T lymphocytes (CTL) in the Tumour nest is crucial in mediating a successful immune response to cancer. The detection and elimination of cancer cells by CTL can be impaired by cancer-mediated immune evasion. In recent years, it has become increasingly clear that not only neoplastic cells themselves, but also cells of the tumour microenvironment (TME) exert immunosuppressive functions and thereby play an integral part in the immune escape of cancer. The most abundant stromal cells of the TME, cancer associated fibroblasts (CAFs), promote tumour progression via multiple pathways and play a role in dampening the immune response to cancer. Recent research indicates that T cells react to CAF signalling and establish bidirectional crosstalk that plays a significant role in the tumour immune response. This review discusses the various mechanisms by which the CAF/T cell crosstalk may impede anti-cancer immunity.
KW - cancer-associated fibroblast (CAF)
KW - mechanisms of immune evasion
KW - T cell exhaustion
KW - targeting CAFs
KW - tumour microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85128838986&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2022.887380
DO - 10.3389/fimmu.2022.887380
M3 - Review article
C2 - 35479076
AN - SCOPUS:85128838986
SN - 1664-3224
VL - 13
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 887380
ER -