Cancer Risk in Collagenous Colitis

Johanna Larsson, Konstantinos J. Dabos, Peter Hoglund, Johan Bohr, Andreas Munch, Andry Giannakou, Artur Nemeth, Gabriele Wurm Johansson, Ervin Toth, John N Plevris, Paul Finerton, Anastasios Koulaouzidis, Klas Sjöberg

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Data on malignancy in patients with collagenous colitis (CC) is scarce. We aimed to determine
the incidence of cancers in patients with CC. In a two-stages, observational study, data on cancers in
patients diagnosed with CC during 2000–2015, were collected from two cohorts. The risk was calculated
according to the age-standardized rate for the first cohort and according to the standardized incidence
ratio for the second cohort. The first cohort comprised 738 patients (394 from Scotland and 344 from
Sweden; mean age 71 ± 11 and 66 ± 13 years, respectively). The incidence rates for lung cancer (RR 3.9,
p = 0.001), bladder cancer (RR 9.2, p = 0.019), and non-melanoma skin cancer (NMSC) (RR 15, p = 0.001)
were increased. As the majority of NMSC cases (15/16) came from Sweden, a second Swedish cohort,
comprising 1141 patients (863 women, mean age 65 years, range 20–95 years) was collected. There were
93 cancer cases (besides NMSC). The risk for colon cancer was decreased (SIR 0.23, p= 0.0087). The risk
for cutaneous squamous cell carcinoma was instead markedly increased (SIR 3.27, p = 0.001).
Original languageEnglish
JournalJournal of Clinical Medicine
DOIs
Publication statusPublished - 11 Nov 2019
Externally publishedYes

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