Carbimazole-associated hypersensitivity vasculitis in a cat

Kelly Blacklock; I Cattin; J Stewart

doi:10.1111/jsap.12154

Carbimazole-associated hypersensitivity vasculitis in a cat

Research output: Contribution to journal › Article › peer-review

Abstract

Feline hyperthyroidism can be treated medically, surgically or with radioactive iodine. Carbimazole inhibits both triiodothyronine and thyroxine synthesis in the thyroid gland and reported side effects include mild eosinophilia, leucopenia and lymphocytosis, thrombocytopenia, elevated liver enzyme activities, gastrointestinal signs and skin abnormalities. This case report describes a cat with carbimazole-associated apparent hypersensitivity vasculitis causing digital and tail necrosis, with multiple renal infarcts. Withdrawal of carbimazole resulted in stable disease.

Original language	English
Pages (from-to)	643-7
Number of pages	5
Journal	Journal of Small Animal Practice
Volume	55
Issue number	12
DOIs	https://doi.org/10.1111/jsap.12154
Publication status	Published - 21 Nov 2013

Keywords / Materials (for Non-textual outputs)

Animals
Antithyroid Agents/adverse effects
Carbimazole/adverse effects
Cat Diseases/chemically induced
Cats
Female
Hyperthyroidism/drug therapy
Vasculitis, Leukocytoclastic, Cutaneous/chemically induced

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10.1111/jsap.12154

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@article{73a16e904605404c87488a7725a4e75e,

title = "Carbimazole-associated hypersensitivity vasculitis in a cat",

abstract = "Feline hyperthyroidism can be treated medically, surgically or with radioactive iodine. Carbimazole inhibits both triiodothyronine and thyroxine synthesis in the thyroid gland and reported side effects include mild eosinophilia, leucopenia and lymphocytosis, thrombocytopenia, elevated liver enzyme activities, gastrointestinal signs and skin abnormalities. This case report describes a cat with carbimazole-associated apparent hypersensitivity vasculitis causing digital and tail necrosis, with multiple renal infarcts. Withdrawal of carbimazole resulted in stable disease. ",

keywords = "Animals, Antithyroid Agents/adverse effects, Carbimazole/adverse effects, Cat Diseases/chemically induced, Cats, Female, Hyperthyroidism/drug therapy, Vasculitis, Leukocytoclastic, Cutaneous/chemically induced",

author = "Kelly Blacklock and I Cattin and J Stewart",

note = "{\textcopyright} 2013 British Small Animal Veterinary Association.",

year = "2013",

month = nov,

day = "21",

doi = "10.1111/jsap.12154",

language = "English",

volume = "55",

pages = "643--7",

journal = "Journal of Small Animal Practice",

issn = "0022-4510",

publisher = "Wiley-Blackwell",

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}

TY - JOUR

T1 - Carbimazole-associated hypersensitivity vasculitis in a cat

AU - Blacklock, Kelly

AU - Cattin, I

AU - Stewart, J

PY - 2013/11/21

Y1 - 2013/11/21

N2 - Feline hyperthyroidism can be treated medically, surgically or with radioactive iodine. Carbimazole inhibits both triiodothyronine and thyroxine synthesis in the thyroid gland and reported side effects include mild eosinophilia, leucopenia and lymphocytosis, thrombocytopenia, elevated liver enzyme activities, gastrointestinal signs and skin abnormalities. This case report describes a cat with carbimazole-associated apparent hypersensitivity vasculitis causing digital and tail necrosis, with multiple renal infarcts. Withdrawal of carbimazole resulted in stable disease.

AB - Feline hyperthyroidism can be treated medically, surgically or with radioactive iodine. Carbimazole inhibits both triiodothyronine and thyroxine synthesis in the thyroid gland and reported side effects include mild eosinophilia, leucopenia and lymphocytosis, thrombocytopenia, elevated liver enzyme activities, gastrointestinal signs and skin abnormalities. This case report describes a cat with carbimazole-associated apparent hypersensitivity vasculitis causing digital and tail necrosis, with multiple renal infarcts. Withdrawal of carbimazole resulted in stable disease.

KW - Animals

KW - Antithyroid Agents/adverse effects

KW - Carbimazole/adverse effects

KW - Cat Diseases/chemically induced

KW - Cats

KW - Female

KW - Hyperthyroidism/drug therapy

KW - Vasculitis, Leukocytoclastic, Cutaneous/chemically induced

U2 - 10.1111/jsap.12154

DO - 10.1111/jsap.12154

M3 - Article

C2 - 24255992

SN - 0022-4510

VL - 55

SP - 643

EP - 647

JO - Journal of Small Animal Practice

JF - Journal of Small Animal Practice

IS - 12

ER -

Carbimazole-associated hypersensitivity vasculitis in a cat

Abstract

Keywords / Materials (for Non-textual outputs)

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