Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells

Murat Bozdag; Marta Ferraroni; Carol Ward; Fabrizio Carta; Silvia Bua; Andrea Angeli; Simon P. Langdon; Ian H. Kunkler; Abdul-malek S. Al-tamimi; Claudiu T. Supuran

doi:10.1016/j.ejmech.2019.111600

Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells

Murat Bozdag, Marta Ferraroni, Carol Ward, Fabrizio Carta, Silvia Bua, Andrea Angeli, Simon P. Langdon, Ian H. Kunkler, Abdul-malek S. Al-tamimi, Claudiu T. Supuran

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	111600
Journal	European Journal of Medicinal Chemistry
Volume	182
Early online date	7 Aug 2019
DOIs	https://doi.org/10.1016/j.ejmech.2019.111600
Publication status	Published - Nov 2019

Access to Document

10.1016/j.ejmech.2019.111600

_EJMC_ms_final
This is a pre-copyedited, author-produced version of an article accepted for publication in European Journal of Medicinal Chemistry following peer review. The version of record "Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells" is available online at:https://doi.org/10.1016/j.ejmech.2019.111600
Accepted author manuscript, 1.41 MBLicence: CC BY-NC-ND

https://linkinghub.elsevier.com/retrieve/pii/S0223523419307342

Simon Langdon
- Deanery of Molecular, Genetic and Population Health Sciences - Visitor: Official Visitor
- Edinburgh Pathology
- Edinburgh Cancer Research Centre
Person: Academic: Research Active , Affiliated Independent Researcher

Cite this

Bozdag, M., Ferraroni, M., Ward, C., Carta, F., Bua, S., Angeli, A., Langdon, S. P., Kunkler, I. H., Al-tamimi, A. S., & Supuran, C. T. (2019). Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells. European Journal of Medicinal Chemistry, 182, 111600. https://doi.org/10.1016/j.ejmech.2019.111600

@article{0473a8cbb80c4c9c895ca049f0ac0af2,

title = "Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells",

author = "Murat Bozdag and Marta Ferraroni and Carol Ward and Fabrizio Carta and Silvia Bua and Andrea Angeli and Langdon, {Simon P.} and Kunkler, {Ian H.} and Al-tamimi, {Abdul-malek S.} and Supuran, {Claudiu T.}",

year = "2019",

month = nov,

doi = "10.1016/j.ejmech.2019.111600",

language = "English",

volume = "182",

pages = "111600",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson SAS",

}

Bozdag, M, Ferraroni, M, Ward, C, Carta, F, Bua, S, Angeli, A, Langdon, SP , Kunkler, IH, Al-tamimi, AS & Supuran, CT 2019, 'Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells', European Journal of Medicinal Chemistry, vol. 182, pp. 111600. https://doi.org/10.1016/j.ejmech.2019.111600

TY - JOUR

T1 - Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells

AU - Bozdag, Murat

AU - Ferraroni, Marta

AU - Ward, Carol

AU - Carta, Fabrizio

AU - Bua, Silvia

AU - Angeli, Andrea

AU - Langdon, Simon P.

AU - Kunkler, Ian H.

AU - Al-tamimi, Abdul-malek S.

AU - Supuran, Claudiu T.

PY - 2019/11

Y1 - 2019/11

U2 - 10.1016/j.ejmech.2019.111600

DO - 10.1016/j.ejmech.2019.111600

M3 - Article

VL - 182

SP - 111600

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

ER -

Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells

Access to Document

Profiles

Simon Langdon

Cite this