Cardiovascular disease in COPD: mechanisms

John D Maclay; William MacNee

doi:10.1378/chest.12-0938

Cardiovascular disease in COPD: mechanisms

Research output: Contribution to journal › Article › peer-review

Abstract

It is now well established that cardiovascular disease contributes significantly to both morbidity and mortality in COPD. Shared risk factors for cardiovascular disease and COPD, such as smoking, low socioeconomic class, and a sedentary lifestyle contribute to the natural history of each of these conditions. However, it is now apparent that alternative, novel mechanisms are involved in the pathogenesis of cardiovascular disease, and these may play an important role in driving the increased cardiovascular risk associated with COPD. In this article, we discuss the potential mechanisms that link COPD to an increased risk of cardiovascular disease.

Original language	English
Pages (from-to)	798-807
Number of pages	10
Journal	Chest Journal
Volume	143
Issue number	3
DOIs	https://doi.org/10.1378/chest.12-0938
Publication status	Published - Mar 2013

Keywords / Materials (for Non-textual outputs)

C-Reactive Protein
Cardiovascular Diseases
Carotid Intima-Media Thickness
Chemokines, CC
Humans
Inflammation
Matrix Metalloproteinase 1
Oxidative Stress
Plaque, Atherosclerotic
Pulmonary Disease, Chronic Obstructive
Risk Factors
Smoking
Vascular Stiffness

Access to Document

10.1378/chest.12-0938

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J. (Principal Investigator)
MRC
1/09/12 → 31/08/16
Project: Research

Cite this

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title = "Cardiovascular disease in COPD: mechanisms",

abstract = "It is now well established that cardiovascular disease contributes significantly to both morbidity and mortality in COPD. Shared risk factors for cardiovascular disease and COPD, such as smoking, low socioeconomic class, and a sedentary lifestyle contribute to the natural history of each of these conditions. However, it is now apparent that alternative, novel mechanisms are involved in the pathogenesis of cardiovascular disease, and these may play an important role in driving the increased cardiovascular risk associated with COPD. In this article, we discuss the potential mechanisms that link COPD to an increased risk of cardiovascular disease.",

keywords = "C-Reactive Protein, Cardiovascular Diseases, Carotid Intima-Media Thickness, Chemokines, CC, Humans, Inflammation, Matrix Metalloproteinase 1, Oxidative Stress, Plaque, Atherosclerotic, Pulmonary Disease, Chronic Obstructive, Risk Factors, Smoking, Vascular Stiffness",

author = "Maclay, {John D} and William MacNee",

year = "2013",

month = mar,

doi = "10.1378/chest.12-0938",

language = "English",

volume = "143",

pages = "798--807",

journal = "Chest Journal",

issn = "0012-3692",

publisher = "Elsevier",

number = "3",

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TY - JOUR

T1 - Cardiovascular disease in COPD

T2 - mechanisms

AU - Maclay, John D

AU - MacNee, William

PY - 2013/3

Y1 - 2013/3

N2 - It is now well established that cardiovascular disease contributes significantly to both morbidity and mortality in COPD. Shared risk factors for cardiovascular disease and COPD, such as smoking, low socioeconomic class, and a sedentary lifestyle contribute to the natural history of each of these conditions. However, it is now apparent that alternative, novel mechanisms are involved in the pathogenesis of cardiovascular disease, and these may play an important role in driving the increased cardiovascular risk associated with COPD. In this article, we discuss the potential mechanisms that link COPD to an increased risk of cardiovascular disease.

AB - It is now well established that cardiovascular disease contributes significantly to both morbidity and mortality in COPD. Shared risk factors for cardiovascular disease and COPD, such as smoking, low socioeconomic class, and a sedentary lifestyle contribute to the natural history of each of these conditions. However, it is now apparent that alternative, novel mechanisms are involved in the pathogenesis of cardiovascular disease, and these may play an important role in driving the increased cardiovascular risk associated with COPD. In this article, we discuss the potential mechanisms that link COPD to an increased risk of cardiovascular disease.

KW - C-Reactive Protein

KW - Cardiovascular Diseases

KW - Carotid Intima-Media Thickness

KW - Chemokines, CC

KW - Humans

KW - Inflammation

KW - Matrix Metalloproteinase 1

KW - Oxidative Stress

KW - Plaque, Atherosclerotic

KW - Pulmonary Disease, Chronic Obstructive

KW - Risk Factors

KW - Smoking

KW - Vascular Stiffness

U2 - 10.1378/chest.12-0938

DO - 10.1378/chest.12-0938

M3 - Article

C2 - 23460157

SN - 0012-3692

VL - 143

SP - 798

EP - 807

JO - Chest Journal

JF - Chest Journal

IS - 3

ER -

Cardiovascular disease in COPD: mechanisms

Abstract

Keywords / Materials (for Non-textual outputs)

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PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

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