Cardiovascular disease in COPD: mechanisms

John D Maclay, William MacNee

Research output: Contribution to journalArticlepeer-review


It is now well established that cardiovascular disease contributes significantly to both morbidity and mortality in COPD. Shared risk factors for cardiovascular disease and COPD, such as smoking, low socioeconomic class, and a sedentary lifestyle contribute to the natural history of each of these conditions. However, it is now apparent that alternative, novel mechanisms are involved in the pathogenesis of cardiovascular disease, and these may play an important role in driving the increased cardiovascular risk associated with COPD. In this article, we discuss the potential mechanisms that link COPD to an increased risk of cardiovascular disease.
Original languageEnglish
Pages (from-to)798-807
Number of pages10
Issue number3
Publication statusPublished - Mar 2013


  • C-Reactive Protein
  • Cardiovascular Diseases
  • Carotid Intima-Media Thickness
  • Chemokines, CC
  • Humans
  • Inflammation
  • Matrix Metalloproteinase 1
  • Oxidative Stress
  • Plaque, Atherosclerotic
  • Pulmonary Disease, Chronic Obstructive
  • Risk Factors
  • Smoking
  • Vascular Stiffness

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