Cardiovascular injury and repair in chronic obstructive pulmonary disease

William Macnee, John Maclay, David McAllister

Research output: Contribution to journalArticlepeer-review


Cardiovascular disease represents a considerable burden in terms of both morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD). For 20 years, forced expiratory volume in 1 second (FEV(1)) has been an established predictor of cardiovascular mortality among smokers, never-smokers, and patients with COPD. We review evidence for increased cardiovascular risk in COPD. In addition, we assess the emerging evidence which suggests that hypoxia, systemic inflammation, and oxidative stress in patients with COPD may cause cardiovascular disease. We also discuss alternative hypotheses that the endothelium and connective tissues in the arteries and lungs of patients with COPD and cardiovascular disease have a shared susceptibility to these factors.
Original languageEnglish
Pages (from-to)824-33
Number of pages10
JournalProceedings of the American Thoracic Society
Issue number8
Publication statusPublished - 2008

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