Carotid intima-media thickness novel loci, sex-specific effects, and genetic correlations with obesity and glucometabolic traits in UK Biobank

Rona J. Strawbridge*, Joey Ward, Mark E.S. Bailey, Breda Cullen, Amy Ferguson, Nicholas Graham, Keira J.A. Johnston, Laura M. Lyall, Robert Pearsall, Jill Pell, Richard J. Shaw, Rachana Tank, Donald M. Lyall, Daniel J. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

OBJECTIVE: Atherosclerosis is the underlying cause of most cardiovascular disease, but mechanisms underlying atherosclerosis are incompletely understood. Ultrasound measurement of the carotid intima-media thickness (cIMT) can be used to measure vascular remodeling, which is indicative of atherosclerosis. Genome-wide association studies have identified many genetic loci associated with cIMT, but heterogeneity of measurements collected by many small cohorts have been a major limitation in these efforts. Here, we conducted genome-wide association analyses in UKB (UK Biobank; N=22 179), the largest single study with consistent cIMT measurements. APPROACH AND RESULTS: We used BOLT-LMM software to run linear regression of cIMT in UKB, adjusted for age, sex, and genotyping chip. In white British participants, we identified 5 novel loci associated with cIMT and replicated most previously reported loci. In the first sex-specific analyses of cIMT, we identified a locus on chromosome 5, associated with cIMT in women only and highlight VCAN as a good candidate gene at this locus. Genetic correlations with body mass index and glucometabolic traits were also observed. Two loci influenced risk of ischemic heart disease. CONCLUSIONS: These findings replicate previously reported associations, highlight novel biology, and provide new directions for investigating the sex differences observed in cardiovascular disease presentation and progression.

Original languageEnglish
Pages (from-to)446-461
Number of pages16
JournalArteriosclerosis, Thrombosis, and Vascular Biology
DOIs
Publication statusPublished - 5 Dec 2019

Keywords / Materials (for Non-textual outputs)

  • Association studies
  • Atherosclerosis
  • Carotid artery
  • Coronary artery disease
  • Diabetes
  • Genetics
  • Intima-media thickness
  • Obesity
  • Type 2

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