Cartilage development and degeneration: a Wnt Wnt situation

Katherine Staines; Vicky Macrae; Colin Farquharson

doi:10.1002/cbf.2852

Cartilage development and degeneration: a Wnt Wnt situation

Katherine Staines, Vicky Macrae, Colin Farquharson

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and endochondral ossification. Therefore, in this review, we discuss Wnt regulation of chondrogenic differentiation, hypertrophy and cartilage function. Moreover, we detail the role of the Wnt signaling pathway in cartilage degeneration and its potential to act as a target for therapy in osteoarthritis. Copyright © 2012 John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	633-642
Journal	Cell Biochemistry and Function
Volume	30
Issue number	8
Early online date	21 Jun 2012
DOIs	https://doi.org/10.1002/cbf.2852
Publication status	Published - 2012

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10.1002/cbf.2852

http://onlinelibrary.wiley.com/doi/10.1002/cbf.2852/abstract

1 Doctoral Thesis

The role of MEPE in chondrocyte matrix mineralisation
Staines, K., 2012
Research output: Thesis › Doctoral Thesis

Cite this

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title = "Cartilage development and degeneration: a Wnt Wnt situation",

abstract = "The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and endochondral ossification. Therefore, in this review, we discuss Wnt regulation of chondrogenic differentiation, hypertrophy and cartilage function. Moreover, we detail the role of the Wnt signaling pathway in cartilage degeneration and its potential to act as a target for therapy in osteoarthritis. Copyright {\textcopyright} 2012 John Wiley & Sons, Ltd.",

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AB - The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and endochondral ossification. Therefore, in this review, we discuss Wnt regulation of chondrogenic differentiation, hypertrophy and cartilage function. Moreover, we detail the role of the Wnt signaling pathway in cartilage degeneration and its potential to act as a target for therapy in osteoarthritis. Copyright © 2012 John Wiley & Sons, Ltd.

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M3 - Article

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JO - Cell Biochemistry and Function

JF - Cell Biochemistry and Function

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Cartilage development and degeneration: a Wnt Wnt situation

Abstract

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Research output

The role of MEPE in chondrocyte matrix mineralisation

Cite this