Cartilage development and degeneration: a Wnt Wnt situation

Katherine Staines, Vicky Macrae, Colin Farquharson

Research output: Contribution to journalArticlepeer-review


The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and endochondral ossification. Therefore, in this review, we discuss Wnt regulation of chondrogenic differentiation, hypertrophy and cartilage function. Moreover, we detail the role of the Wnt signaling pathway in cartilage degeneration and its potential to act as a target for therapy in osteoarthritis. Copyright © 2012 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)633-642
JournalCell Biochemistry and Function
Issue number8
Early online date21 Jun 2012
Publication statusPublished - 2012


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