Cartilage to bone transitions in health and disease

Katherine Staines, Andrea Sophie Pollard, Imelda M McGonnell, Colin Farquharson, Andrew Anthony Pitsillides

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Aberrant redeployment of the 'transient' events responsible for bone development and postnatal longitudinal growth has been reported in some diseases in what is otherwise inherently 'stable' cartilage. Lessons may be learnt from the molecular mechanisms underpinning transient chondrocyte differentiation and function, and their application may better identify disease aetiology. Here we review the current evidence supporting this possibility. We firstly outline endochondral ossification and the cellular and physiological mechanisms by which it is controlled in the postnatal growth plate. We then compare the biology of these transient cartilaginous structures to the inherently stable articular cartilage. Finally, we highlight specific scenarios in which the redeployment of these embryonic processes may contribute to disease development, with the foresight that deciphering those mechanisms regulating pathological changes and loss of cartilage stability will aid future research into effective disease-modifying therapies.
Original languageEnglish
Pages (from-to)R1-12
Number of pages12
JournalJournal of Endocrinology
Volume219
Issue number1
Early online date19 Aug 2013
DOIs
Publication statusPublished - Oct 2013

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