Ca2+ activity signatures of myelin sheath formation and growth in vivo

Marion Baraban, Sigrid Koudelka, David A Lyons

Research output: Contribution to journalArticlepeer-review

Abstract

During myelination, individual oligodendrocytes initially over-produce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca2+ activity in vivo, we find that high-amplitude, long-duration Ca2+ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca2+ transient activity in sheaths precedes faster elongation. Our data implicate local Ca2+ signaling in regulating distinct stages of myelination.

Original languageEnglish
Pages (from-to)19–23
Number of pages5
JournalNature Neuroscience
Volume21
Issue number1
Early online date11 Dec 2017
DOIs
Publication statusPublished - 31 Jan 2018

Keywords

  • Journal Article

Fingerprint Dive into the research topics of 'Ca<sup>2+</sup> activity signatures of myelin sheath formation and growth in vivo'. Together they form a unique fingerprint.

Cite this