Ca2+ activity signatures of myelin sheath formation and growth in vivo

Marion Baraban; Sigrid Koudelka; David A Lyons

doi:10.1038/s41593-017-0040-x

Ca²⁺ activity signatures of myelin sheath formation and growth in vivo

Marion Baraban, Sigrid Koudelka, David A Lyons

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

During myelination, individual oligodendrocytes initially over-produce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca²⁺ activity in vivo, we find that high-amplitude, long-duration Ca²⁺ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca²⁺ transient activity in sheaths precedes faster elongation. Our data implicate local Ca²⁺ signaling in regulating distinct stages of myelination.

Original language	English
Pages (from-to)	19–23
Number of pages	5
Journal	Nature Neuroscience
Volume	21
Issue number	1
Early online date	11 Dec 2017
DOIs	https://doi.org/10.1038/s41593-017-0040-x
Publication status	Published - 31 Jan 2018

Keywords / Materials (for Non-textual outputs)

Journal Article

Access to Document

10.1038/s41593-017-0040-x

Baraban_et_al_NN_BC58553Accepted author manuscript, 1.52 MB

Cite this

@article{e28016b90e2c4e3e985e03755b3c7f47,

title = "Ca2+ activity signatures of myelin sheath formation and growth in vivo",

abstract = "During myelination, individual oligodendrocytes initially over-produce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca2+ activity in vivo, we find that high-amplitude, long-duration Ca2+ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca2+ transient activity in sheaths precedes faster elongation. Our data implicate local Ca2+ signaling in regulating distinct stages of myelination.",

keywords = "Journal Article",

author = "Marion Baraban and Sigrid Koudelka and Lyons, {David A}",

year = "2018",

month = jan,

day = "31",

doi = "10.1038/s41593-017-0040-x",

language = "English",

volume = "21",

pages = "19–23",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Ca2+ activity signatures of myelin sheath formation and growth in vivo

AU - Baraban, Marion

AU - Koudelka, Sigrid

AU - Lyons, David A

PY - 2018/1/31

Y1 - 2018/1/31

N2 - During myelination, individual oligodendrocytes initially over-produce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca2+ activity in vivo, we find that high-amplitude, long-duration Ca2+ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca2+ transient activity in sheaths precedes faster elongation. Our data implicate local Ca2+ signaling in regulating distinct stages of myelination.

AB - During myelination, individual oligodendrocytes initially over-produce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca2+ activity in vivo, we find that high-amplitude, long-duration Ca2+ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca2+ transient activity in sheaths precedes faster elongation. Our data implicate local Ca2+ signaling in regulating distinct stages of myelination.

KW - Journal Article

U2 - 10.1038/s41593-017-0040-x

DO - 10.1038/s41593-017-0040-x

M3 - Article

C2 - 29230058

SN - 1097-6256

VL - 21

SP - 19

EP - 23

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 1

ER -

Ca²⁺ activity signatures of myelin sheath formation and growth in vivo

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Other files and links

Fingerprint

David Lyons

Cite this

Ca2+ activity signatures of myelin sheath formation and growth in vivo

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Other files and links

Fingerprint

Profiles

David Lyons

Cite this

Ca²⁺ activity signatures of myelin sheath formation and growth in vivo