Ca2+ activity signatures of myelin sheath formation and growth in vivo

Marion Baraban, Sigrid Koudelka, David A Lyons

Research output: Contribution to journalArticlepeer-review


During myelination, individual oligodendrocytes initially over-produce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca2+ activity in vivo, we find that high-amplitude, long-duration Ca2+ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca2+ transient activity in sheaths precedes faster elongation. Our data implicate local Ca2+ signaling in regulating distinct stages of myelination.

Original languageEnglish
Pages (from-to)19–23
Number of pages5
JournalNature Neuroscience
Issue number1
Early online date11 Dec 2017
Publication statusPublished - 31 Jan 2018


  • Journal Article

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