During myelination, individual oligodendrocytes initially over-produce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca2+ activity in vivo, we find that high-amplitude, long-duration Ca2+ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca2+ transient activity in sheaths precedes faster elongation. Our data implicate local Ca2+ signaling in regulating distinct stages of myelination.
- Journal Article
- Deanery of Biomedical Sciences - Personal Chair of Neurobiology
- Centre for Discovery Brain Sciences
- Euan MacDonald Centre for Motor Neurone Disease Research
- Edinburgh Neuroscience
Person: Academic: Research Active