Abstract / Description of output
Chiral phosphoric acid-catalyzed asymmetric aldehyde prenylation has been established using an α,α-dimethyl allyl boronic ester. The transformation provides an expedient access to a wide array of aryl, heteroaryl, aryl-substituted alkenyl as well as primary and secondary aliphatic homoprenyl alcohols with excellent asymmetric induction. The utility of this asymmetric catalysis strategy has been demonstrated through a short and efficient total synthesis of the two natural products (‒)-rosiridol and (‒)-bifurcadiol.
Original language | English |
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Journal | Chemical Communications |
Early online date | 20 Jul 2020 |
DOIs | |
Publication status | E-pub ahead of print - 20 Jul 2020 |