Cathepsin D SNP associated with increased risk of variant Creutzfeldt-Jakob disease

Matthew T Bishop, Gabor G Kovacs, Pascual Sanchez-Juan, Richard S G Knight

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Variant Creutzfeldt-Jakob disease (vCJD) originally resulted from the consumption of foodstuffs contaminated by bovine spongiform encephalopathy (BSE) material, with 163 confirmed cases in the UK to date. Many thousands are likely to have been exposed to dietary infection and so it is important (for surveillance, epidemic modelling, public health and understanding pathogenesis) to identify genetic factors that may affect individual susceptibility to infection. This study looked at a polymorphism in the cathepsin D gene (refSNP ID: rs17571) previously examined in Alzheimer's disease (AD).
Original languageEnglish
Pages (from-to)31
JournalBMC Medical Genetics
Publication statusPublished - 2008

Keywords / Materials (for Non-textual outputs)

  • Adolescent
  • Adult
  • Cathepsin D
  • Child
  • Cohort Studies
  • Creutzfeldt-Jakob Syndrome
  • Female
  • Genotype
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Mutation
  • Polymorphism, Single Nucleotide
  • Risk Factors


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