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Abstract / Description of output
Background and Purpose-Studies in patients with lacunar stroke often assess the number of lacunes. However, data on how many symptomatic lacunar infarcts cavitate into a lacune are limited. We assessed the evolution of symptomatic lacunar infarcts over 2-year follow-up.
Methods-In 82 patients with first-ever lacunar stroke with a lacunar infarct in the deep brain regions (excluding the centrum semiovale), we performed a brain MR at presentation and 2 years later. We classified cavitation of lacunar infarcts at baseline and on follow-up MR as absent, incomplete, or complete. We recorded time to imaging, infarct size, and vascular risk factors.
Results-On baseline MR, 38 (46%) index infarcts showed complete or incomplete cavitation. Median time to imaging was 8 (0-73) days in noncavitated and 63 (1-184) days in cavitated lesions (P <0.05). On follow-up imaging, 94% of the lacunar infarcts were completely or incompletely cavitated, most had reduced in diameter, and 5 (6%) had disappeared. Vascular risk factors were not associated with cavitation.
Conclusion-Cavitation and lesion shrinkage were seen in almost all symptomatic lacunar infarcts in the deep brain regions over 2-year follow-up. Counting lacunes in these specific regions at a random moment might slightly, however not substantially, underestimate the burden of deep lacunar infarction.
Original language | English |
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Pages (from-to) | 2245-2247 |
Number of pages | 3 |
Journal | Stroke |
Volume | 43 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2012 |
Keywords / Materials (for Non-textual outputs)
- lacunar infarcts
- MRI
- lacunes
- cerebral small vessel disease
- CENTRUM OVALE INFARCTS
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- 1 Finished
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STANDARD FOR DTERMINING THE VASCULAR CONTRIBUTION TO NEURODEGENERATION
1/03/12 → 31/08/13
Project: Research