Projects per year
Abstract
The importance of selective macroautophagy/autophagy in cellular health is increasingly evident. The selective degradation of portions of the endoplasmic reticulum (ER), or reticulophagy, is an emerging example but requires further mechanistic detail and broad evidence of physiological relevance. In a recent study, we identified CCPG1, an ER-resident transmembrane protein that can bind to Atg8-family proteins and, independently and discretely, to RB1CC1/FIP200. Both of these interactions are required to facilitate CCPG1's function as a reticulophagy cargo receptor. CCPG1 transcripts are inducible by ER stress, providing a direct link between ER stress and reticulophagy. In vivo, CCPG1 prevents the hyper-accumulation of insoluble protein within the ER lumen of pancreatic acinar cells and alleviates ER stress. Accordingly, CCPG1 loss sensitizes the exocrine pancreas to tissue injury.
Original language | English |
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Pages (from-to) | 1-2 |
Number of pages | 2 |
Journal | Autophagy |
Early online date | 19 Jun 2018 |
DOIs | |
Publication status | E-pub ahead of print - 19 Jun 2018 |
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Dive into the research topics of 'CCPG1, a cargo receptor required for reticulophagy and endoplasmic reticulum proteostasis'. Together they form a unique fingerprint.Projects
- 2 Finished
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A new negative regulator of autophagy in cellular and organismal homoeostasis
1/01/16 → 31/12/18
Project: Research
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TBK1 KINASE ADDICTION IN KRAS-DEPENDENT NON SMALL LUNG CANCER: THE ROLE OF AUTOPHAGY
1/02/12 → 31/12/18
Project: Research