Projects per year
Abstract
ER stress-mediated induction of a new vertebrate-specific autophagy cargo receptor, CCPG1 (cell-cycle progression gene 1), drives degradation of endoplasmic reticulum. CCPG1 acts via ATG8-family interaction and, non-canonically, via discrete interactions with FIP200. CCPG1 ameliorates ER stress in the exocrine pancreas. This has potential implications for inflammation and cancer, discussed here
Original language | English |
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Pages (from-to) | 01-10 |
Journal | Molecular and cellular oncology |
Early online date | 26 Feb 2018 |
DOIs | |
Publication status | E-pub ahead of print - 26 Feb 2018 |
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Dive into the research topics of 'CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health'. Together they form a unique fingerprint.Projects
- 2 Finished
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A new negative regulator of autophagy in cellular and organismal homoeostasis
1/01/16 → 31/12/18
Project: Research
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TBK1 KINASE ADDICTION IN KRAS-DEPENDENT NON SMALL LUNG CANCER: THE ROLE OF AUTOPHAGY
1/02/12 → 31/12/18
Project: Research