CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health

Matthew D. Smith, Simon Wilkinson

Research output: Contribution to journalArticlepeer-review

Abstract

ER stress-mediated induction of a new vertebrate-specific autophagy cargo receptor, CCPG1 (cell-cycle progression gene 1), drives degradation of endoplasmic reticulum. CCPG1 acts via ATG8-family interaction and, non-canonically, via discrete interactions with FIP200. CCPG1 ameliorates ER stress in the exocrine pancreas. This has potential implications for inflammation and cancer, discussed here
Original languageEnglish
Pages (from-to)01-10
JournalMolecular and cellular oncology
Early online date26 Feb 2018
DOIs
Publication statusE-pub ahead of print - 26 Feb 2018

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