Projects per year
The murine serous cavities contain a rare and enigmatic population of short-lived F4/80loMHCII+ macrophages but what regulates their development, survival and fate is unclear. Here, we show that mature F4/80loMHCII+ peritoneal macrophages arise post-birth, but that this occurs largely independently of colonisation by microbiota. Rather, microbiota specifically regulate development of a subpopulation of CD11c+ cells that express the immunoregulatory cytokine RELM, are reliant on the transcription factor EGR2, and develop independently of the growth factor CSF1. Furthermore, we demonstrate that intrinsic expression of RELM, a signature marker shared by CD11c+ and CD11c– F4/80loMHCII+ cavity macrophages, regulates survival and differentiation of these cells in the peritoneal cavity in a sex-specific manner. Thus, we identify a previously unappreciated diversity in serous cavity F4/80loMHCII+ macrophages that is regulated by microbiota, and describe a novel sex and site-specific function for RELM in regulating macrophage endurance that reveals the unique survival challenge presented to monocyte-derived macrophages by the female peritoneal environment.
|Journal||European Journal of Immunology|
|Early online date||24 May 2022|
|Publication status||Published - 4 Aug 2022|
FingerprintDive into the research topics of 'CD11c identifies microbiota and EGR2-dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice'. Together they form a unique fingerprint.
Wellcome Trust Tissue Repair PhD Programme MAIN AWARD
Forbes, S., Hansen, C. & Rossi, A.
11/09/17 → 30/09/23
Investigating the role of TGF¿¿ in the functional imprinting of pulmonary macrophages in health and disease
1/09/17 → 31/12/23
The parameters of tissue resident macrophage autonomy
1/07/14 → 30/06/17