CD46 plasticity and its inflammatory bias in multiple sclerosis

Siobhan Ni Choileain, Anne L Astier

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Known as a link to the adaptive immune system, a complement regulator, a "pathogen magnet" and more recently as an inducer of autophagy, CD46 is the human receptor that refuses to be put in a box. This review summarizes the current roles of CD46 during immune responses and highlights the role of CD46 as both a promoter and attenuator of the immune response. In patients with multiple sclerosis (MS), CD46 responses are overwhelmingly pro-inflammatory with notable defects in cytokine and chemokine production. Understanding the role of CD46 as an inflammatory regulator is a distant goal considering the darkness in which its regulatory mechanisms reside. Further research into the regulation of CD46 expression through its internalization and processing will undoubtedly extend our knowledge of how the balance is tipped in favor of inflammation in MS patients.
Original languageEnglish
Pages (from-to)49-59
Number of pages11
JournalArchivum immunologiae et therapiae experimentalis
Issue number1
Publication statusPublished - 2011

Keywords / Materials (for Non-textual outputs)

  • Adaptive Immunity
  • Amyloid Precursor Protein Secretases
  • Animals
  • Antigens, CD46
  • Autophagy
  • Cell Movement
  • Complement Activation
  • Humans
  • Inflammation Mediators
  • Interleukins
  • Matrix Metalloproteinases
  • Multiple Sclerosis
  • Presenilins
  • T-Lymphocytes


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