CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitro model

Mahmoud Orazizadeh, Herng Sheng Lee, Bianca Groenendijk, S Jane Millward Sadler, Malcolm O Wright, Frederik P Lindberg, Donald M Salter

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies provide evidence of roles for integrins in mechanical signalling in bone and cartilage. Integrin signalling is modulated by various mechanisms, including interaction with other transmembrane proteins. We aimed to identify whether one such protein, integrin-associated protein (CD47/IAP), is expressed by chondrocytes and whether it may regulate integrin-dependent mechanotransduction.
Original languageEnglish
Article numberR4
Number of pages11
JournalArthritis Research and Therapy
Volume10
Issue number1
DOIs
Publication statusPublished - 2008

Fingerprint

Dive into the research topics of 'CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitro model'. Together they form a unique fingerprint.

Cite this