CD8- dendritic cell activation status plays an integral role in influencing Th2 response development

A S MacDonald, A D Straw, B Bauman, E J Pearce, Andrew MacDonald

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Whether dendritic cells (DC) play a passive or active role in Th2 response induction is poorly understood. In this study, we show that CD8- DC pulsed with Th2-polarizing Ag (soluble egg Ag (SEA)) from Schistosoma mansoni potently stimulate Th2 responses in vivo and in vitro while failing to undergo a conventional maturation process. Thus, in contrast to DC pulsed with the Th1 response inducing Ag Propionebacterium acnes, SEA-exposed DC exhibit a phenotype that is most similar to that of immature DC, failing to up-regulate expression of CD40, CD54, CD80, CD86, or OX40L; producing no detectable IL-4, IL-10, or IL-12; and displaying only a minor increase in MHC class II expression. Importantly, in vitro derived DC exposed to SEA were phenotypically similar to CD8- DC isolated from active S. mansoni infection. By discriminating between different types of pathogen and responding appropriately, CD8- DC play a major role in the decision process to mount either a Th1 or Th2 response.
Original languageEnglish
Pages (from-to)1982-8
Number of pages7
JournalThe Journal of Immunology
Volume167
Issue number4
Publication statusPublished - 2001

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Antigens, Bacterial
  • Antigens, CD40
  • Antigens, CD8
  • Antigens, Helminth
  • Cells, Cultured
  • Dendritic Cells
  • Female
  • Immunophenotyping
  • Interleukin-12
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Propionibacterium acnes
  • Schistosoma mansoni
  • Th1 Cells
  • Th2 Cells

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