Cdc14-Dependent Dephosphorylation of a Kinetochore Protein Prior to Anaphase in Saccharomyces cerevisiae

Bungo Akiyoshi; Sue Biggins

doi:10.1534/genetics.110.123653

Cdc14-Dependent Dephosphorylation of a Kinetochore Protein Prior to Anaphase in Saccharomyces cerevisiae

Bungo Akiyoshi, Sue Biggins^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The budding yeast Cdc14 phosphatase reverses Cdk1 phosphorylation to promote mitotic exit. Although Cdc14 activity is thought to be restricted to anaphase, we found that dephosphorylation of the Dsn1 kinetochore protein in metaphase requires Cdc14. These data suggest that there is a nonnucleolar pool of active Cdc14 prior to anaphase.

Original language	English
Pages (from-to)	1487-1491
Number of pages	5
Journal	Genetics
Volume	186
Issue number	4
DOIs	https://doi.org/10.1534/genetics.110.123653
Publication status	Published - 1 Dec 2010
Externally published	Yes

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title = "Cdc14-Dependent Dephosphorylation of a Kinetochore Protein Prior to Anaphase in Saccharomyces cerevisiae",

abstract = "The budding yeast Cdc14 phosphatase reverses Cdk1 phosphorylation to promote mitotic exit. Although Cdc14 activity is thought to be restricted to anaphase, we found that dephosphorylation of the Dsn1 kinetochore protein in metaphase requires Cdc14. These data suggest that there is a nonnucleolar pool of active Cdc14 prior to anaphase.",

author = "Bungo Akiyoshi and Sue Biggins",

year = "2010",

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doi = "10.1534/genetics.110.123653",

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AU - Biggins, Sue

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N2 - The budding yeast Cdc14 phosphatase reverses Cdk1 phosphorylation to promote mitotic exit. Although Cdc14 activity is thought to be restricted to anaphase, we found that dephosphorylation of the Dsn1 kinetochore protein in metaphase requires Cdc14. These data suggest that there is a nonnucleolar pool of active Cdc14 prior to anaphase.

AB - The budding yeast Cdc14 phosphatase reverses Cdk1 phosphorylation to promote mitotic exit. Although Cdc14 activity is thought to be restricted to anaphase, we found that dephosphorylation of the Dsn1 kinetochore protein in metaphase requires Cdc14. These data suggest that there is a nonnucleolar pool of active Cdc14 prior to anaphase.

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U2 - 10.1534/genetics.110.123653

DO - 10.1534/genetics.110.123653

M3 - Article

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SN - 0016-6731

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JO - Genetics

JF - Genetics

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ER -

Cdc14-Dependent Dephosphorylation of a Kinetochore Protein Prior to Anaphase in Saccharomyces cerevisiae

Abstract

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