TY - JOUR
T1 - CDK9 inhibitors push cancer cells over the edge
AU - Nowicki, Matthew W
AU - Walkinshaw, Malcolm D
N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.
PY - 2010/10
Y1 - 2010/10
N2 - The trouble with CDK active-site inhibitors is their tendency to have off-target effects. This is not surprising, as the ATP binding sites of most protein kinases are very similar. Wang et al. (2010) have used some clever screening approaches to identify selective CDK9 inhibitors that drive cancer cells into apoptosis.
AB - The trouble with CDK active-site inhibitors is their tendency to have off-target effects. This is not surprising, as the ATP binding sites of most protein kinases are very similar. Wang et al. (2010) have used some clever screening approaches to identify selective CDK9 inhibitors that drive cancer cells into apoptosis.
UR - http://www.scopus.com/inward/record.url?scp=78049363156&partnerID=8YFLogxK
U2 - 10.1016/j.chembiol.2010.10.003
DO - 10.1016/j.chembiol.2010.10.003
M3 - Editorial
C2 - 21035725
SN - 1074-5521
VL - 17
SP - 1047
EP - 1048
JO - Chemistry and Biology
JF - Chemistry and Biology
IS - 10
ER -