CDKN2A mutation and deletion status in thin and thick primary melanoma

A R Cachia, J O Indsto, K M McLaren, G J Mann, M J Arends

Research output: Contribution to journalArticlepeer-review


Human melanoma cell lines and tumor tissue from familial and sporadic melanomas have frequent, nonrandom chromosomal breaks and deletions on chromosome 9p21, a region that includes the tumor suppressor gene CDKN2A/p16INK4A. Germ-line mutations within this gene have been observed in some familial melanoma kindreds, but somatic mutation in sporadic primary melanoma is infrequent. Thirty-nine archival, paraffin-embedded, sporadic, primary cutaneous malignant melanomas (20 >3-mm-thick and 19
Original languageEnglish
Pages (from-to)3511-5
Number of pages5
JournalClinical Cancer Research
Issue number9
Publication statusPublished - Sep 2000


  • Chromosomes, Human, Pair 9
  • DNA Mutational Analysis
  • Female
  • Genes, p16
  • Humans
  • Loss of Heterozygosity
  • Male
  • Melanoma
  • Middle Aged
  • Neoplasm Staging
  • Polymerase Chain Reaction
  • Polymorphism, Single-Stranded Conformational
  • Skin Neoplasms


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