CDKN2A mutation and deletion status in thin and thick primary melanoma

A R Cachia; J O Indsto; K M McLaren; G J Mann; M J Arends

CDKN2A mutation and deletion status in thin and thick primary melanoma

A R Cachia, J O Indsto, K M McLaren, G J Mann, M J Arends

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Human melanoma cell lines and tumor tissue from familial and sporadic melanomas have frequent, nonrandom chromosomal breaks and deletions on chromosome 9p21, a region that includes the tumor suppressor gene CDKN2A/p16INK4A. Germ-line mutations within this gene have been observed in some familial melanoma kindreds, but somatic mutation in sporadic primary melanoma is infrequent. Thirty-nine archival, paraffin-embedded, sporadic, primary cutaneous malignant melanomas (20 >3-mm-thick and 19

Original language	English
Pages (from-to)	3511-5
Number of pages	5
Journal	Clinical Cancer Research
Volume	6
Issue number	9
Publication status	Published - Sept 2000

Keywords / Materials (for Non-textual outputs)

Chromosomes, Human, Pair 9
DNA Mutational Analysis
Female
Genes, p16
Humans
Loss of Heterozygosity
Male
Melanoma
Middle Aged
Neoplasm Staging
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Skin Neoplasms

Cite this

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title = "CDKN2A mutation and deletion status in thin and thick primary melanoma",

abstract = "Human melanoma cell lines and tumor tissue from familial and sporadic melanomas have frequent, nonrandom chromosomal breaks and deletions on chromosome 9p21, a region that includes the tumor suppressor gene CDKN2A/p16INK4A. Germ-line mutations within this gene have been observed in some familial melanoma kindreds, but somatic mutation in sporadic primary melanoma is infrequent. Thirty-nine archival, paraffin-embedded, sporadic, primary cutaneous malignant melanomas (20 >3-mm-thick and 19 ",

keywords = "Chromosomes, Human, Pair 9, DNA Mutational Analysis, Female, Genes, p16, Humans, Loss of Heterozygosity, Male, Melanoma, Middle Aged, Neoplasm Staging, Polymerase Chain Reaction, Polymorphism, Single-Stranded Conformational, Skin Neoplasms",

author = "Cachia, {A R} and Indsto, {J O} and McLaren, {K M} and Mann, {G J} and Arends, {M J}",

year = "2000",

month = sep,

language = "English",

volume = "6",

pages = "3511--5",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

number = "9",

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TY - JOUR

T1 - CDKN2A mutation and deletion status in thin and thick primary melanoma

AU - Cachia, A R

AU - Indsto, J O

AU - McLaren, K M

AU - Mann, G J

AU - Arends, M J

PY - 2000/9

Y1 - 2000/9

N2 - Human melanoma cell lines and tumor tissue from familial and sporadic melanomas have frequent, nonrandom chromosomal breaks and deletions on chromosome 9p21, a region that includes the tumor suppressor gene CDKN2A/p16INK4A. Germ-line mutations within this gene have been observed in some familial melanoma kindreds, but somatic mutation in sporadic primary melanoma is infrequent. Thirty-nine archival, paraffin-embedded, sporadic, primary cutaneous malignant melanomas (20 >3-mm-thick and 19

AB - Human melanoma cell lines and tumor tissue from familial and sporadic melanomas have frequent, nonrandom chromosomal breaks and deletions on chromosome 9p21, a region that includes the tumor suppressor gene CDKN2A/p16INK4A. Germ-line mutations within this gene have been observed in some familial melanoma kindreds, but somatic mutation in sporadic primary melanoma is infrequent. Thirty-nine archival, paraffin-embedded, sporadic, primary cutaneous malignant melanomas (20 >3-mm-thick and 19

KW - Chromosomes, Human, Pair 9

KW - DNA Mutational Analysis

KW - Female

KW - Genes, p16

KW - Humans

KW - Loss of Heterozygosity

KW - Male

KW - Melanoma

KW - Middle Aged

KW - Neoplasm Staging

KW - Polymerase Chain Reaction

KW - Polymorphism, Single-Stranded Conformational

KW - Skin Neoplasms

M3 - Article

C2 - 10999737

SN - 1078-0432

VL - 6

SP - 3511

EP - 3515

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 9

ER -

CDKN2A mutation and deletion status in thin and thick primary melanoma

Abstract

Keywords / Materials (for Non-textual outputs)

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