Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry

V G Brunton; I R J MacPherson; M C Frame

doi:10.1016/j.bbamcr.2004.04.010

Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry

V G Brunton, I R J MacPherson, M C Frame

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The interaction of cells with surrounding matrix and neighbouring cells governs many aspects of cell behaviour. Aside from transmitting signals from the external environment, adhesion receptors also receive signals from the cell interior. Here we review the interrelationship between adhesion receptors, tyrosine kinases (both growth factor receptor and non-receptor) and modulators of the actin cytoskeletal network. Deregulation of many aspects of these signalling pathways in cancer highlights the need for a better understanding of the complexities involved.

Original language	English
Pages (from-to)	121-44
Number of pages	24
Journal	BBA - Bioenergetics
Volume	1692
Issue number	2-3
DOIs	https://doi.org/10.1016/j.bbamcr.2004.04.010
Publication status	Published - 5 Jul 2004

Keywords / Materials (for Non-textual outputs)

Actins
Adherens Junctions
Animals
Binding Sites
Cadherins
Cytoskeleton
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Humans
Integrins
Neoplasms
Protein-Tyrosine Kinases
p120 GTPase Activating Protein
src-Family Kinases

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10.1016/j.bbamcr.2004.04.010

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@article{05c147345cea47fcb7d38e875309c796,

title = "Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry",

abstract = "The interaction of cells with surrounding matrix and neighbouring cells governs many aspects of cell behaviour. Aside from transmitting signals from the external environment, adhesion receptors also receive signals from the cell interior. Here we review the interrelationship between adhesion receptors, tyrosine kinases (both growth factor receptor and non-receptor) and modulators of the actin cytoskeletal network. Deregulation of many aspects of these signalling pathways in cancer highlights the need for a better understanding of the complexities involved.",

keywords = "Actins, Adherens Junctions, Animals, Binding Sites, Cadherins, Cytoskeleton, Focal Adhesion Kinase 1, Focal Adhesion Protein-Tyrosine Kinases, Humans, Integrins, Neoplasms, Protein-Tyrosine Kinases, p120 GTPase Activating Protein, src-Family Kinases",

author = "Brunton, {V G} and MacPherson, {I R J} and Frame, {M C}",

year = "2004",

month = jul,

day = "5",

doi = "10.1016/j.bbamcr.2004.04.010",

language = "English",

volume = "1692",

pages = "121--44",

journal = "BBA - Bioenergetics",

issn = "0005-2728",

publisher = "Elsevier",

number = "2-3",

}

TY - JOUR

T1 - Cell adhesion receptors, tyrosine kinases and actin modulators

T2 - a complex three-way circuitry

AU - Brunton, V G

AU - MacPherson, I R J

AU - Frame, M C

PY - 2004/7/5

Y1 - 2004/7/5

N2 - The interaction of cells with surrounding matrix and neighbouring cells governs many aspects of cell behaviour. Aside from transmitting signals from the external environment, adhesion receptors also receive signals from the cell interior. Here we review the interrelationship between adhesion receptors, tyrosine kinases (both growth factor receptor and non-receptor) and modulators of the actin cytoskeletal network. Deregulation of many aspects of these signalling pathways in cancer highlights the need for a better understanding of the complexities involved.

AB - The interaction of cells with surrounding matrix and neighbouring cells governs many aspects of cell behaviour. Aside from transmitting signals from the external environment, adhesion receptors also receive signals from the cell interior. Here we review the interrelationship between adhesion receptors, tyrosine kinases (both growth factor receptor and non-receptor) and modulators of the actin cytoskeletal network. Deregulation of many aspects of these signalling pathways in cancer highlights the need for a better understanding of the complexities involved.

KW - Actins

KW - Adherens Junctions

KW - Animals

KW - Binding Sites

KW - Cadherins

KW - Cytoskeleton

KW - Focal Adhesion Kinase 1

KW - Focal Adhesion Protein-Tyrosine Kinases

KW - Humans

KW - Integrins

KW - Neoplasms

KW - Protein-Tyrosine Kinases

KW - p120 GTPase Activating Protein

KW - src-Family Kinases

U2 - 10.1016/j.bbamcr.2004.04.010

DO - 10.1016/j.bbamcr.2004.04.010

M3 - Article

C2 - 15246683

SN - 0005-2728

VL - 1692

SP - 121

EP - 144

JO - BBA - Bioenergetics

JF - BBA - Bioenergetics

IS - 2-3

ER -

Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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