Cell-mediated immunity in herpes simplex virus-infected mice: functional analysis of lymph node cells during periods of acute and latent infection, with reference to cytotoxic and memory cells

Anthony Nash, R Quartey-Papafio, Peter Wildy

Research output: Contribution to journalArticlepeer-review

Abstract

The functional characteristics of lymphoid cells were investigated during acute and latent infection of mice with herpes simplex virus (HSV). Cytotoxic T cells were found in the draining lymph node (DLN) 4 days p.i. and had reached maximum activity between 6 and 9 days. After the 12th day and during the period of latent infection (> 20 days) no cytotoxic cell activity was observed. Cytotoxic activity could only be detected when the lymphoid cells had been cultured for a period of 3 days. In general, the cell killing was specific for syngeneic infected target cells, although some killing of uninfected targets was observed. In contrast to the cytotoxic response, DLN cells responding to HSV in a proliferation assay were detected towards the end of the acute phase and at lease up to 9 months thereafter. The significance of these observations for the pathogenesis of HSV is discussed.
Original languageEnglish
Pages (from-to)309-17
Number of pages9
JournalJournal of General Virology
Volume49
Issue number2
Publication statusPublished - Aug 1980

Keywords

  • Acute Disease
  • Animals
  • Chronic Disease
  • Cytotoxicity, Immunologic
  • Herpes Simplex/immunology
  • Immunity, Cellular
  • Immunologic Memory
  • Lymph Nodes/cytology
  • Mice
  • Mice, Inbred BALB C/immunology
  • Simplexvirus/immunology
  • T-Lymphocytes/immunology

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