Cell-mediated immunity in herpes simplex virus-infected mice: H-2 mapping of the delayed-type hypersensitivity response and the antiviral T cell response

Anthony Nash, J Phelan, Peter Wildy

Research output: Contribution to journalArticlepeer-review

Abstract

An adoptive transfer system was used to investigate the H-2 restriction of delayed-type hypersensitivity (DTH) to herpes simplex virus. A successful DTH transfer was achieved when donor and recipient were compatible at the I-A region, with K and D region compatibility unnecessary. However, the rapid clearance of infectious virus from the inoculation site was found only when the donor and recipients were compatible at H-2K (and presumably D) and I-A regions.
Original languageEnglish
Pages (from-to)1260-2
Number of pages3
JournalJournal of Immunology
Volume126
Issue number4
Publication statusPublished - Apr 1981

Keywords

  • Animals
  • Antibodies, Viral/biosynthesis
  • Chromosome Mapping
  • Female
  • H-2 Antigens/genetics
  • Herpes Simplex/immunology
  • Hypersensitivity, Delayed/immunology
  • Immunity, Cellular
  • Immunization, Passive
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Simplexvirus/immunology
  • T-Lymphocytes/immunology

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