Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats

Dorothy Tse, Lucia Privitera, Anna C Norton, Francesco Gobbo, Patrick Spooner, Tomonori Takeuchi, Stephen J Martin, Richard G M Morris

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Memory formation is typically divided into phases associated with encoding, storage, consolidation, and retrieval. The neural determinants of these phases are thought to differ. This study first investigated the impact of the experience of novelty in rats incurred at a different time, before or after, the precise moment of memory encoding. Memory retention was enhanced. Optogenetic activation of the locus coeruleus mimicked this enhancement induced by novelty, both when given before and after the moment of encoding. Optogenetic activation of the locus coeruleus also induced a slow-onset potentiation of field potentials in area CA1 of the hippocampus evoked by CA3 stimulation. Despite the locus coeruleus being considered a primarily noradrenergic area, both effects of such stimulation were blocked by the dopamine D1/D5 receptor antagonist SCH 23390. These findings substantiate and enrich the evidence implicating the locus coeruleus in cellular aspects of memory consolidation in hippocampus.

Original languageEnglish
Pages (from-to)e2307275120
JournalProceedings of the National Academy of Sciences of the United States of America
Volume120
Issue number46
DOIs
Publication statusPublished - 6 Nov 2023

Keywords / Materials (for Non-textual outputs)

  • Rats
  • Animals
  • Locus Coeruleus/physiology
  • Optogenetics
  • Hippocampus/physiology
  • Neurons/physiology
  • Norepinephrine/pharmacology
  • Long-Term Potentiation/physiology

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