Cellular control of protein levels: A systems biology perspective

Victoria Munro, Van Kelly, Christoph B. Messner, Georg Kustatscher*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Abstract How cells regulate protein levels is a central question of biology. Over the past decades, molecular biology research has provided profound insights into the mechanisms and the molecular machinery governing each step of the gene expression process, from transcription to protein degradation. Recent advances in transcriptomics and proteomics have complemented our understanding of these fundamental cellular processes with a quantitative, systems-level perspective. Multi-omic studies revealed significant quantitative, kinetic and functional differences between the genome, transcriptome and proteome. While protein levels often correlate with mRNA levels, quantitative investigations have demonstrated a substantial impact of translation and protein degradation on protein expression control. In addition, protein-level regulation appears to play a crucial role in buffering protein abundances against undesirable mRNA expression variation. These findings have practical implications for many fields, including gene function prediction and precision medicine.
Original languageEnglish
Article number2200220
Number of pages14
Publication statusPublished - 27 Nov 2023

Keywords / Materials (for Non-textual outputs)

  • proteome
  • transcriptome
  • turnover kinetics
  • mRNA-to-protein correlations
  • protein-level buffering


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