Cellular mechanisms underlying the protective effects of preoperative feeding: a randomized study investigating muscle and liver glycogen content, mitochondrial function, gene and protein expression

Sherif Awad, Dumitru Constantin-Teodosiu, Despina Constantin, Brian J Rowlands, Kenneth C H Fearon, Ian A Macdonald, Dileep N Lobo

Research output: Contribution to journalArticlepeer-review

Abstract

To investigate the effects of preoperative feeding with a carbohydrate-based drink that also contained glutamine and antioxidants (oral nutritional supplement [ONS], Fresenuis Kabi, Germany) on glycogen reserves, mitochondrial function, and the expression of key metabolic genes and proteins.
Original languageEnglish
Pages (from-to)247-53
Number of pages7
JournalAnnals of Surgery
Volume252
Issue number2
DOIs
Publication statusPublished - 2010

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antioxidants
  • Chi-Square Distribution
  • Cholecystectomy, Laparoscopic
  • Dietary Carbohydrates
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Forkhead Transcription Factors
  • Gene Expression
  • Glucose
  • Glutamine
  • Humans
  • Liver Glycogen
  • Male
  • Metallothionein
  • Middle Aged
  • Mitochondria
  • Muscle, Skeletal
  • Oxidative Stress
  • Placebos
  • Preoperative Care
  • Protein-Serine-Threonine Kinases
  • Reverse Transcriptase Polymerase Chain Reaction
  • Statistics, Nonparametric

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