Cellular mechanisms underlying the protective effects of preoperative feeding: a randomized study investigating muscle and liver glycogen content, mitochondrial function, gene and protein expression

Sherif Awad; Dumitru Constantin-Teodosiu; Despina Constantin; Brian J Rowlands; Kenneth C H Fearon; Ian A Macdonald; Dileep N Lobo

doi:10.1097/SLA.0b013e3181e8fbe6

Cellular mechanisms underlying the protective effects of preoperative feeding: a randomized study investigating muscle and liver glycogen content, mitochondrial function, gene and protein expression

Sherif Awad, Dumitru Constantin-Teodosiu, Despina Constantin, Brian J Rowlands, Kenneth C H Fearon, Ian A Macdonald, Dileep N Lobo

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

To investigate the effects of preoperative feeding with a carbohydrate-based drink that also contained glutamine and antioxidants (oral nutritional supplement [ONS], Fresenuis Kabi, Germany) on glycogen reserves, mitochondrial function, and the expression of key metabolic genes and proteins.

Original language	English
Pages (from-to)	247-53
Number of pages	7
Journal	Annals of Surgery
Volume	252
Issue number	2
DOIs	https://doi.org/10.1097/SLA.0b013e3181e8fbe6
Publication status	Published - 2010

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Antioxidants
Chi-Square Distribution
Cholecystectomy, Laparoscopic
Dietary Carbohydrates
Dietary Supplements
Double-Blind Method
Female
Forkhead Transcription Factors
Gene Expression
Glucose
Glutamine
Humans
Liver Glycogen
Male
Metallothionein
Middle Aged
Mitochondria
Muscle, Skeletal
Oxidative Stress
Placebos
Preoperative Care
Protein-Serine-Threonine Kinases
Reverse Transcriptase Polymerase Chain Reaction
Statistics, Nonparametric

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10.1097/SLA.0b013e3181e8fbe6

Cite this

Awad, S., Constantin-Teodosiu, D., Constantin, D., Rowlands, B. J., Fearon, K. C. H., Macdonald, I. A., & Lobo, D. N. (2010). Cellular mechanisms underlying the protective effects of preoperative feeding: a randomized study investigating muscle and liver glycogen content, mitochondrial function, gene and protein expression. Annals of Surgery, 252(2), 247-53. https://doi.org/10.1097/SLA.0b013e3181e8fbe6

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title = "Cellular mechanisms underlying the protective effects of preoperative feeding: a randomized study investigating muscle and liver glycogen content, mitochondrial function, gene and protein expression",

abstract = "To investigate the effects of preoperative feeding with a carbohydrate-based drink that also contained glutamine and antioxidants (oral nutritional supplement [ONS], Fresenuis Kabi, Germany) on glycogen reserves, mitochondrial function, and the expression of key metabolic genes and proteins.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Antioxidants, Chi-Square Distribution, Cholecystectomy, Laparoscopic, Dietary Carbohydrates, Dietary Supplements, Double-Blind Method, Female, Forkhead Transcription Factors, Gene Expression, Glucose, Glutamine, Humans, Liver Glycogen, Male, Metallothionein, Middle Aged, Mitochondria, Muscle, Skeletal, Oxidative Stress, Placebos, Preoperative Care, Protein-Serine-Threonine Kinases, Reverse Transcriptase Polymerase Chain Reaction, Statistics, Nonparametric",

author = "Sherif Awad and Dumitru Constantin-Teodosiu and Despina Constantin and Rowlands, {Brian J} and Fearon, {Kenneth C H} and Macdonald, {Ian A} and Lobo, {Dileep N}",

year = "2010",

doi = "10.1097/SLA.0b013e3181e8fbe6",

language = "English",

volume = "252",

pages = "247--53",

journal = "Annals of Surgery",

issn = "0003-4932",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

Awad, S, Constantin-Teodosiu, D, Constantin, D, Rowlands, BJ, Fearon, KCH, Macdonald, IA & Lobo, DN 2010, 'Cellular mechanisms underlying the protective effects of preoperative feeding: a randomized study investigating muscle and liver glycogen content, mitochondrial function, gene and protein expression', Annals of Surgery, vol. 252, no. 2, pp. 247-53. https://doi.org/10.1097/SLA.0b013e3181e8fbe6

Cellular mechanisms underlying the protective effects of preoperative feeding: a randomized study investigating muscle and liver glycogen content, mitochondrial function, gene and protein expression. / Awad, Sherif; Constantin-Teodosiu, Dumitru; Constantin, Despina et al.

In: Annals of Surgery, Vol. 252, No. 2, 2010, p. 247-53.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cellular mechanisms underlying the protective effects of preoperative feeding: a randomized study investigating muscle and liver glycogen content, mitochondrial function, gene and protein expression

AU - Awad, Sherif

AU - Constantin-Teodosiu, Dumitru

AU - Constantin, Despina

AU - Rowlands, Brian J

AU - Fearon, Kenneth C H

AU - Macdonald, Ian A

AU - Lobo, Dileep N

PY - 2010

Y1 - 2010

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KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antioxidants

KW - Chi-Square Distribution

KW - Cholecystectomy, Laparoscopic

KW - Dietary Carbohydrates

KW - Dietary Supplements

KW - Double-Blind Method

KW - Female

KW - Forkhead Transcription Factors

KW - Gene Expression

KW - Glucose

KW - Glutamine

KW - Humans

KW - Liver Glycogen

KW - Male

KW - Metallothionein

KW - Middle Aged

KW - Mitochondria

KW - Muscle, Skeletal

KW - Oxidative Stress

KW - Placebos

KW - Preoperative Care

KW - Protein-Serine-Threonine Kinases

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Statistics, Nonparametric

U2 - 10.1097/SLA.0b013e3181e8fbe6

DO - 10.1097/SLA.0b013e3181e8fbe6

M3 - Article

C2 - 20622656

VL - 252

SP - 247

EP - 253

JO - Annals of Surgery

JF - Annals of Surgery

SN - 0003-4932

IS - 2

ER -

Cellular mechanisms underlying the protective effects of preoperative feeding: a randomized study investigating muscle and liver glycogen content, mitochondrial function, gene and protein expression

Abstract

Keywords

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