Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals

Grahame McKenzie, George Ward, Yvette Stallwood, Emmanuel Briend, Sofia Papadia, Andrew Lennard, Martin Turner, Brian Champion, Giles E Hardingham

Research output: Contribution to journalArticlepeer-review

Abstract

Notch plays a wide-ranging role in controlling cell fate, differentiation and development. The PI3K-Akt pathway is a similarly conserved signalling pathway which regulates processes such as differentiation, proliferation and survival. Mice with disrupted Notch and PI3K signalling show phenotypic similarities during haematopoietic cell development, suggesting functional interaction between these pathways.
Original languageEnglish
Pages (from-to)10
JournalBMC Cell Biology
Volume7
DOIs
Publication statusPublished - 2006

Keywords

  • Animals
  • Antigens, CD4
  • CHO Cells
  • Cells, Cultured
  • Cricetinae
  • Glycogen Synthase Kinase 3
  • Humans
  • Jurkat Cells
  • Lithium Chloride
  • Models, Biological
  • Neurons
  • Phosphatidylinositol 3-Kinases
  • Rats
  • Receptors, Notch
  • Signal Transduction
  • T-Lymphocytes

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