Cellular reprogramming and epigenetic rejuvenation

Daniel J. Simpson*, Nelly N. Olova, Tamir Chandra

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. However, these techniques usually involve complete dedifferentiation, i.e. somatic cell identity is lost as cells are converted to a pluripotent state. Separating the rejuvenative properties of reprogramming from dedifferentiation is a promising prospect, termed epigenetic rejuvenation. Reprogramming-induced rejuvenation strategies currently involve using Yamanaka factors (typically transiently expressed to prevent full dedifferentiation) and are promising candidates to safely reduce biological age. Here, we review the development and potential of reprogramming-induced rejuvenation as an anti-ageing strategy.

Original languageEnglish
Article number170
JournalClinical Epigenetics
Volume13
Issue number1
DOIs
Publication statusPublished - 6 Sep 2021

Keywords

  • Ageing
  • Cellular reprogramming
  • Epigenetic age
  • Epigenetic clocks
  • Rejuvenation
  • Reprogramming-induced rejuvenation
  • Transient reprogramming

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