TY - JOUR
T1 - Cellular reprogramming and epigenetic rejuvenation
AU - Simpson, Daniel J.
AU - Olova, Nelly N.
AU - Chandra, Tamir
N1 - Funding Information:
D.J.S. is funded by the Medical Research Council (Doctoral Training Programme in Precision Medicine), N.O. is funded by the Medical Research Council (MR/S034676/1) andT.C. is a Chancellor’s Fellow at the University of Edinburgh.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/9/6
Y1 - 2021/9/6
N2 - Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. However, these techniques usually involve complete dedifferentiation, i.e. somatic cell identity is lost as cells are converted to a pluripotent state. Separating the rejuvenative properties of reprogramming from dedifferentiation is a promising prospect, termed epigenetic rejuvenation. Reprogramming-induced rejuvenation strategies currently involve using Yamanaka factors (typically transiently expressed to prevent full dedifferentiation) and are promising candidates to safely reduce biological age. Here, we review the development and potential of reprogramming-induced rejuvenation as an anti-ageing strategy.
AB - Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. However, these techniques usually involve complete dedifferentiation, i.e. somatic cell identity is lost as cells are converted to a pluripotent state. Separating the rejuvenative properties of reprogramming from dedifferentiation is a promising prospect, termed epigenetic rejuvenation. Reprogramming-induced rejuvenation strategies currently involve using Yamanaka factors (typically transiently expressed to prevent full dedifferentiation) and are promising candidates to safely reduce biological age. Here, we review the development and potential of reprogramming-induced rejuvenation as an anti-ageing strategy.
KW - Ageing
KW - Cellular reprogramming
KW - Epigenetic age
KW - Epigenetic clocks
KW - Rejuvenation
KW - Reprogramming-induced rejuvenation
KW - Transient reprogramming
UR - http://www.scopus.com/inward/record.url?scp=85114279022&partnerID=8YFLogxK
U2 - 10.1186/s13148-021-01158-7
DO - 10.1186/s13148-021-01158-7
M3 - Review article
C2 - 34488874
AN - SCOPUS:85114279022
SN - 1868-7075
VL - 13
JO - Clinical Epigenetics
JF - Clinical Epigenetics
IS - 1
M1 - 170
ER -