CENTRAL 6-HYDROXYDOPAMINE LESIONS DECREASE MINERALOCORTICOID, BUT NOT GLUCOCORTICOID RECEPTOR GENE-EXPRESSION IN THE RAT HIPPOCAMPUS

J L W  YAU; J R  SECKL

CENTRAL 6-HYDROXYDOPAMINE LESIONS DECREASE MINERALOCORTICOID, BUT NOT GLUCOCORTICOID RECEPTOR GENE-EXPRESSION IN THE RAT HIPPOCAMPUS

Deanery of Clinical Sciences

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Abstract / Description of output

The role of hippocampal noradrenergic inputs in the modulation of corticosteroid receptor expression has been investigated. Adult male rats were given central 6-hydroxydopamine (6-OHDA) and the expression of hippocampal mineralocorticoid (MR) and glucocorticoid (GR) receptor mRNA was examined after two weeks by in situ hybridization histochemistry. Expression of MR mRNA was significantly decreased in all subregions of the hippocampus except CA2, but 6-OHDA lesions had no effect on GR mRNA expression. These data reveal differential regulation of the two receptor types by noradrenergic inputs.

Original language	English
Pages (from-to)	159-162
Number of pages	4
Journal	Neuroscience Letters
Volume	142
Issue number	2
Publication status	Published - 17 Aug 1992

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title = "CENTRAL 6-HYDROXYDOPAMINE LESIONS DECREASE MINERALOCORTICOID, BUT NOT GLUCOCORTICOID RECEPTOR GENE-EXPRESSION IN THE RAT HIPPOCAMPUS",

abstract = "The role of hippocampal noradrenergic inputs in the modulation of corticosteroid receptor expression has been investigated. Adult male rats were given central 6-hydroxydopamine (6-OHDA) and the expression of hippocampal mineralocorticoid (MR) and glucocorticoid (GR) receptor mRNA was examined after two weeks by in situ hybridization histochemistry. Expression of MR mRNA was significantly decreased in all subregions of the hippocampus except CA2, but 6-OHDA lesions had no effect on GR mRNA expression. These data reveal differential regulation of the two receptor types by noradrenergic inputs.",

author = "YAU, {J L W} and SECKL, {J R}",

year = "1992",

month = aug,

day = "17",

language = "English",

volume = "142",

pages = "159--162",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier",

number = "2",

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T1 - CENTRAL 6-HYDROXYDOPAMINE LESIONS DECREASE MINERALOCORTICOID, BUT NOT GLUCOCORTICOID RECEPTOR GENE-EXPRESSION IN THE RAT HIPPOCAMPUS

AU - YAU, J L W

AU - SECKL, J R

PY - 1992/8/17

Y1 - 1992/8/17

N2 - The role of hippocampal noradrenergic inputs in the modulation of corticosteroid receptor expression has been investigated. Adult male rats were given central 6-hydroxydopamine (6-OHDA) and the expression of hippocampal mineralocorticoid (MR) and glucocorticoid (GR) receptor mRNA was examined after two weeks by in situ hybridization histochemistry. Expression of MR mRNA was significantly decreased in all subregions of the hippocampus except CA2, but 6-OHDA lesions had no effect on GR mRNA expression. These data reveal differential regulation of the two receptor types by noradrenergic inputs.

AB - The role of hippocampal noradrenergic inputs in the modulation of corticosteroid receptor expression has been investigated. Adult male rats were given central 6-hydroxydopamine (6-OHDA) and the expression of hippocampal mineralocorticoid (MR) and glucocorticoid (GR) receptor mRNA was examined after two weeks by in situ hybridization histochemistry. Expression of MR mRNA was significantly decreased in all subregions of the hippocampus except CA2, but 6-OHDA lesions had no effect on GR mRNA expression. These data reveal differential regulation of the two receptor types by noradrenergic inputs.

M3 - Article

SN - 0304-3940

VL - 142

SP - 159

EP - 162

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

CENTRAL 6-HYDROXYDOPAMINE LESIONS DECREASE MINERALOCORTICOID, BUT NOT GLUCOCORTICOID RECEPTOR GENE-EXPRESSION IN THE RAT HIPPOCAMPUS

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