Central and systemic inflammatory responses to thoracotomy - potential implications for acute and chronic post surgical pain

RM Talbot, Kevin McCarthy, C McCrory

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic postsurgical pain (CPSP) may affect up to 70% of patients after surgery. Glial and immune mediators have been implicated in the pathogenesis of chronic postsurgical pain. Our objective was to study cerebrospinal fluid (CSF) and serum concentrations of IL-1β, IL-6, IL-8, IL-10, IFNγ and TNFα over a 72-hour period in patients undergoing a thoracotomy and oesophagectomy. Despite adequate pain control, thoracotomy was still associated with significant central and peripheral inflammation. This must be taken into consideration in planning future strategies to prevent CPSP.
Original languageEnglish
Pages (from-to)147-149
JournalJournal of Neuroimmunology
Volume285
Early online date21 Jun 2015
DOIs
Publication statusPublished - 15 Aug 2015

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