Central nervous system regeneration is driven by microglia necroptosis and repopulation

Amy F. Lloyd; Claire L. Davies; Rebecca K. Holloway; Yasmine Labrak; Graeme Ireland; Dario Carradori; Alessandra Dillenburg; Eva Borger; Daniel Soong; Jill C. Richardson; Tanja Kuhlmann; Anna Williams; Jeffrey W. Pollard; Anne des Rieux; Josef Priller; Veronique E. Miron

doi:10.1038/s41593-019-0418-z

Central nervous system regeneration is driven by microglia necroptosis and repopulation

Amy F. Lloyd, Claire L. Davies, Rebecca K. Holloway, Yasmine Labrak, Graeme Ireland, Dario Carradori, Alessandra Dillenburg, Eva Borger, Daniel Soong, Jill C. Richardson, Tanja Kuhlmann, Anna Williams, Jeffrey W. Pollard, Anne des Rieux, Josef Priller, Veronique E. Miron

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.

Original language	English
Pages (from-to)	1046–1052
Number of pages	7
Journal	Nature Neuroscience
Volume	22
Issue number	7
Early online date	10 Jun 2019
DOIs	https://doi.org/10.1038/s41593-019-0418-z
Publication status	Published - 31 Jul 2019

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https://europepmc.org/article/MED/31182869

MRC Centre for Reproductive Health at the University of Edinburgh
Pollard, J.
MRC
12/09/16 → 11/09/22
Project: Research
Targeting activin receptors as a novel approach to promote myelin repair in the central nervous system
Miron, V.
MRC
1/06/15 → 31/05/20
Project: Research
Assessment of immunomodulatory compounds in driving M1 to M2 microglia macrophage activation switch in models of myelin injury and repair
Miron, V.
BBSRC
1/10/14 → 30/09/18
Project: Research

Veronica Miron
- Deanery of Biomedical Sciences - UoE Honorary staff
- Edinburgh Neuroscience
- Centre for Reproductive Health
Person: Academic: Research Active , Affiliated Independent Researcher

Cite this

Lloyd, A. F., Davies, C. L., Holloway, R. K., Labrak, Y., Ireland, G., Carradori, D., Dillenburg, A., Borger, E., Soong, D., Richardson, J. C., Kuhlmann, T., Williams, A., Pollard, J. W., des Rieux, A., Priller, J., & Miron, V. E. (2019). Central nervous system regeneration is driven by microglia necroptosis and repopulation. Nature Neuroscience, 22(7), 1046–1052. https://doi.org/10.1038/s41593-019-0418-z

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title = "Central nervous system regeneration is driven by microglia necroptosis and repopulation",

abstract = "Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.",

author = "Lloyd, {Amy F.} and Davies, {Claire L.} and Holloway, {Rebecca K.} and Yasmine Labrak and Graeme Ireland and Dario Carradori and Alessandra Dillenburg and Eva Borger and Daniel Soong and Richardson, {Jill C.} and Tanja Kuhlmann and Anna Williams and Pollard, {Jeffrey W.} and {des Rieux}, Anne and Josef Priller and Miron, {Veronique E.}",

year = "2019",

month = jul,

day = "31",

doi = "10.1038/s41593-019-0418-z",

language = "English",

volume = "22",

pages = "1046–1052",

journal = "Nature Neuroscience",

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number = "7",

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Lloyd, AF, Davies, CL, Holloway, RK, Labrak, Y, Ireland, G, Carradori, D, Dillenburg, A, Borger, E, Soong, D, Richardson, JC, Kuhlmann, T, Williams, A, Pollard, JW, des Rieux, A, Priller, J & Miron, VE 2019, 'Central nervous system regeneration is driven by microglia necroptosis and repopulation', Nature Neuroscience, vol. 22, no. 7, pp. 1046–1052. https://doi.org/10.1038/s41593-019-0418-z

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T1 - Central nervous system regeneration is driven by microglia necroptosis and repopulation

AU - Lloyd, Amy F.

AU - Davies, Claire L.

AU - Holloway, Rebecca K.

AU - Labrak, Yasmine

AU - Ireland, Graeme

AU - Carradori, Dario

AU - Dillenburg, Alessandra

AU - Borger, Eva

AU - Soong, Daniel

AU - Richardson, Jill C.

AU - Kuhlmann, Tanja

AU - Williams, Anna

AU - Pollard, Jeffrey W.

AU - des Rieux, Anne

AU - Priller, Josef

AU - Miron, Veronique E.

PY - 2019/7/31

Y1 - 2019/7/31

N2 - Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.

AB - Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.

U2 - 10.1038/s41593-019-0418-z

DO - 10.1038/s41593-019-0418-z

M3 - Article

SN - 1097-6256

VL - 22

SP - 1046

EP - 1052

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 7

ER -

Central nervous system regeneration is driven by microglia necroptosis and repopulation

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Projects

MRC Centre for Reproductive Health at the University of Edinburgh

Targeting activin receptors as a novel approach to promote myelin repair in the central nervous system

Assessment of immunomodulatory compounds in driving M1 to M2 microglia macrophage activation switch in models of myelin injury and repair

Profiles

Veronica Miron

Cite this