Central synapses release a resource-efficient amount of glutamate

Leonid P Savtchenko, Serigy Sylantyev, Dmitri A Rusakov

Research output: Contribution to journalArticlepeer-review


Why synapses release a certain amount of neurotransmitter is poorly understood. We combined patch-clamp electrophysiology with computer simulations to estimate how much glutamate is discharged at two distinct central synapses of the rat. We found that, regardless of some uncertainty over synaptic microenvironment, synapses generate the maximal current per released glutamate molecule while maximizing signal information content. Our result suggests that synapses operate on a principle of resource optimization.
Original languageEnglish
Pages (from-to)10-12
Number of pages3
JournalNature Neuroscience
Issue number1
Publication statusPublished - Jan 2013


  • Animals
  • Biophysics
  • Cerebellum
  • Computer Simulation
  • Dipeptides
  • Dose-Response Relationship, Drug
  • Electric Stimulation
  • Entropy
  • Excitatory Postsynaptic Potentials
  • Glutamic Acid
  • Hippocampus
  • Male
  • Models, Neurological
  • Monte Carlo Method
  • Mossy Fibers, Hippocampal
  • Nerve Fibers
  • Neurons
  • Patch-Clamp Techniques
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, AMPA
  • Synapses


Dive into the research topics of 'Central synapses release a resource-efficient amount of glutamate'. Together they form a unique fingerprint.

Cite this