Centromere chromatin structure - Lessons from neocentromeres

Research output: Contribution to journalReview articlepeer-review

Abstract

Centromeres are highly specialized genomic loci that function during mitosis to maintain genome stability. Formed primarily on repetitive α-satellite DNA sequence characterisation of native centromeric chromatin structure has remained challenging. Fortuitously, neocentromeres are formed on a unique DNA sequence and represent an excellent model to interrogate centromeric chromatin structure. This review uncovers the specific findings from independent neocentromere studies that have advanced our understanding of canonical centromere chromatin structure.

Original languageEnglish
Pages (from-to)111899
JournalExperimental Cell Research
Early online date8 Feb 2020
DOIs
Publication statusE-pub ahead of print - 8 Feb 2020

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