Centromere chromatin structure - Lessons from neocentromeres

Catherine Naughton; Nick Gilbert

doi:10.1016/j.yexcr.2020.111899

Centromere chromatin structure - Lessons from neocentromeres

Research output: Contribution to journal › Review article › peer-review

Abstract

Centromeres are highly specialized genomic loci that function during mitosis to maintain genome stability. Formed primarily on repetitive α-satellite DNA sequence characterisation of native centromeric chromatin structure has remained challenging. Fortuitously, neocentromeres are formed on a unique DNA sequence and represent an excellent model to interrogate centromeric chromatin structure. This review uncovers the specific findings from independent neocentromere studies that have advanced our understanding of canonical centromere chromatin structure.

Original language	English
Pages (from-to)	111899
Journal	Experimental Cell Research
Early online date	8 Feb 2020
DOIs	https://doi.org/10.1016/j.yexcr.2020.111899
Publication status	E-pub ahead of print - 8 Feb 2020

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10.1016/j.yexcr.2020.111899Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

Centromere chromatin structure – Lessons from neocentromeresAccepted author manuscript, 868 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

Chromatin architecture and regulation
Gilbert, N. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research

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title = "Centromere chromatin structure - Lessons from neocentromeres",

abstract = "Centromeres are highly specialized genomic loci that function during mitosis to maintain genome stability. Formed primarily on repetitive α-satellite DNA sequence characterisation of native centromeric chromatin structure has remained challenging. Fortuitously, neocentromeres are formed on a unique DNA sequence and represent an excellent model to interrogate centromeric chromatin structure. This review uncovers the specific findings from independent neocentromere studies that have advanced our understanding of canonical centromere chromatin structure.",

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doi = "10.1016/j.yexcr.2020.111899",

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T1 - Centromere chromatin structure - Lessons from neocentromeres

AU - Naughton, Catherine

AU - Gilbert, Nick

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N2 - Centromeres are highly specialized genomic loci that function during mitosis to maintain genome stability. Formed primarily on repetitive α-satellite DNA sequence characterisation of native centromeric chromatin structure has remained challenging. Fortuitously, neocentromeres are formed on a unique DNA sequence and represent an excellent model to interrogate centromeric chromatin structure. This review uncovers the specific findings from independent neocentromere studies that have advanced our understanding of canonical centromere chromatin structure.

AB - Centromeres are highly specialized genomic loci that function during mitosis to maintain genome stability. Formed primarily on repetitive α-satellite DNA sequence characterisation of native centromeric chromatin structure has remained challenging. Fortuitously, neocentromeres are formed on a unique DNA sequence and represent an excellent model to interrogate centromeric chromatin structure. This review uncovers the specific findings from independent neocentromere studies that have advanced our understanding of canonical centromere chromatin structure.

U2 - 10.1016/j.yexcr.2020.111899

DO - 10.1016/j.yexcr.2020.111899

M3 - Review article

C2 - 32044308

SN - 0014-4827

SP - 111899

JO - Experimental Cell Research

JF - Experimental Cell Research

ER -

Centromere chromatin structure - Lessons from neocentromeres

Abstract

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Projects

Chromatin architecture and regulation

Cite this