Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Kassandra Kisler; Amy R Nelson; Axel Montagne; Berislav V Zlokovic

doi:10.1038/nrn.2017.48

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Kassandra Kisler, Amy R Nelson, Axel Montagne, Berislav V Zlokovic

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian brain has evolved a unique mechanism for CBF control known as neurovascular coupling. This mechanism ensures a rapid increase in the rate of CBF and oxygen delivery to activated brain structures. The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. This Review article examines the cellular and molecular mechanisms within the neurovascular unit that contribute to CBF control, and neurovascular dysfunction in neurodegenerative disorders such as Alzheimer disease.

Original language	English
Pages (from-to)	419-434
Number of pages	16
Journal	Nature Reviews Neuroscience
Volume	18
Issue number	7
DOIs	https://doi.org/10.1038/nrn.2017.48
Publication status	Published - Jul 2017

Keywords / Materials (for Non-textual outputs)

Alzheimer Disease/complications
Brain/blood supply
Cerebrovascular Circulation/physiology
Cerebrovascular Disorders/complications
Humans
Models, Neurological
Neurovascular Coupling/physiology

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10.1038/nrn.2017.48

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@article{7486307bd29b4c8bb22cb25acdd70ca6,

title = "Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease",

abstract = "Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian brain has evolved a unique mechanism for CBF control known as neurovascular coupling. This mechanism ensures a rapid increase in the rate of CBF and oxygen delivery to activated brain structures. The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. This Review article examines the cellular and molecular mechanisms within the neurovascular unit that contribute to CBF control, and neurovascular dysfunction in neurodegenerative disorders such as Alzheimer disease.",

keywords = "Alzheimer Disease/complications, Brain/blood supply, Cerebrovascular Circulation/physiology, Cerebrovascular Disorders/complications, Humans, Models, Neurological, Neurovascular Coupling/physiology",

author = "Kassandra Kisler and Nelson, {Amy R} and Axel Montagne and Zlokovic, {Berislav V}",

year = "2017",

month = jul,

doi = "10.1038/nrn.2017.48",

language = "English",

volume = "18",

pages = "419--434",

journal = "Nature Reviews Neuroscience",

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T1 - Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

AU - Kisler, Kassandra

AU - Nelson, Amy R

AU - Montagne, Axel

AU - Zlokovic, Berislav V

PY - 2017/7

Y1 - 2017/7

N2 - Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian brain has evolved a unique mechanism for CBF control known as neurovascular coupling. This mechanism ensures a rapid increase in the rate of CBF and oxygen delivery to activated brain structures. The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. This Review article examines the cellular and molecular mechanisms within the neurovascular unit that contribute to CBF control, and neurovascular dysfunction in neurodegenerative disorders such as Alzheimer disease.

AB - Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian brain has evolved a unique mechanism for CBF control known as neurovascular coupling. This mechanism ensures a rapid increase in the rate of CBF and oxygen delivery to activated brain structures. The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. This Review article examines the cellular and molecular mechanisms within the neurovascular unit that contribute to CBF control, and neurovascular dysfunction in neurodegenerative disorders such as Alzheimer disease.

KW - Alzheimer Disease/complications

KW - Brain/blood supply

KW - Cerebrovascular Circulation/physiology

KW - Cerebrovascular Disorders/complications

KW - Humans

KW - Models, Neurological

KW - Neurovascular Coupling/physiology

U2 - 10.1038/nrn.2017.48

DO - 10.1038/nrn.2017.48

M3 - Review article

C2 - 28515434

SN - 1471-003X

VL - 18

SP - 419

EP - 434

JO - Nature Reviews Neuroscience

JF - Nature Reviews Neuroscience

IS - 7

ER -

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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