Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Kassandra Kisler, Amy R Nelson, Axel Montagne, Berislav V Zlokovic

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian brain has evolved a unique mechanism for CBF control known as neurovascular coupling. This mechanism ensures a rapid increase in the rate of CBF and oxygen delivery to activated brain structures. The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. This Review article examines the cellular and molecular mechanisms within the neurovascular unit that contribute to CBF control, and neurovascular dysfunction in neurodegenerative disorders such as Alzheimer disease.

Original languageEnglish
Pages (from-to)419-434
Number of pages16
JournalNature Reviews Neuroscience
Issue number7
Publication statusPublished - Jul 2017

Keywords / Materials (for Non-textual outputs)

  • Alzheimer Disease/complications
  • Brain/blood supply
  • Cerebrovascular Circulation/physiology
  • Cerebrovascular Disorders/complications
  • Humans
  • Models, Neurological
  • Neurovascular Coupling/physiology


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