Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats

E L Bailey, J M Wardlaw, D Graham, A F Dominiczak, C L M Sudlow, C Smith

Research output: Contribution to journalArticlepeer-review

Abstract

The spontaneously hypertensive stroke-prone rat (SHRSP) is a potential animal model of human lacunar stroke, but there is little information on SHRSP small vessel pathology, especially in young rats. We investigated the structural changes that occur in cortical and subcortical vessels and adjacent tissue in SHRSP before, during and after the onset of hypertension.
Original languageEnglish
Pages (from-to)711-26
Number of pages16
JournalNeuropathology and Applied Neurobiology
Volume37
Issue number7
DOIs
Publication statusPublished - 11 Mar 2011

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